{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:59:52Z","timestamp":1783126792005,"version":"3.54.6"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T00:00:00Z","timestamp":1479168000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National College Students\u2019 Innovation and Entrepreneurship Training Program of China","award":["201510680001"],"award-info":[{"award-number":["201510680001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2016,11,15]]},"abstract":"<jats:p>The main aim of the study was to prove the compensative effect of intestine for renal function. Rat kidney was impaired by intragastrically administrating adenine (400\u2009mg per day for 5 days). Intestinal tract was harvested and equally divided into 20 segments except cecum. Kidneys were harvested and histologically examined with hematoxylin-eosin staining kits. Uric acid, urea (BUN), and creatinine in serum were determined with assay kits, and BUN and creatinine in every intestinal segment were also determined. The results showed that adenine was able to increase uric acid level in serum from <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mn fontstyle=\"italic\">20.98<\/a:mn>\n                        <a:mo>\u00b1<\/a:mo>\n                        <a:mn fontstyle=\"italic\">6.98<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>\u2009\u03bcg\/mL to <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <e:mn fontstyle=\"italic\">40.77<\/e:mn>\n                        <e:mo>\u00b1<\/e:mo>\n                        <e:mn fontstyle=\"italic\">7<\/e:mn>\n                        <e:mo>.<\/e:mo>\n                        <e:mn fontstyle=\"italic\">52<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>\u2009\u03bcg\/mL and cause renal function damage with BUN (from <jats:inline-formula>\n                     <j:math xmlns:j=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <j:mn fontstyle=\"italic\">3.87<\/j:mn>\n                        <j:mo>\u00b1<\/j:mo>\n                        <j:mn fontstyle=\"italic\">0.62<\/j:mn>\n                     <\/j:math>\n                  <\/jats:inline-formula>\u2009mM to 12.<jats:inline-formula>\n                     <n:math xmlns:n=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <n:mn fontstyle=\"italic\">33<\/n:mn>\n                        <n:mo>\u00b1<\/n:mo>\n                        <n:mn fontstyle=\"italic\">3.27<\/n:mn>\n                     <\/n:math>\n                  <\/jats:inline-formula>\u2009mM) and creatinine (from <jats:inline-formula>\n                     <r:math xmlns:r=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <r:mn fontstyle=\"italic\">51.48<\/r:mn>\n                        <r:mo>\u00b1<\/r:mo>\n                        <r:mn fontstyle=\"italic\">6.98<\/r:mn>\n                        <r:mo>\u2009<\/r:mo>\n                     <\/r:math>\n                  <\/jats:inline-formula>\u03bcM to <jats:inline-formula>\n                     <v:math xmlns:v=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <v:mn fontstyle=\"italic\">118.25<\/v:mn>\n                        <v:mo>\u00b1<\/v:mo>\n                        <v:mn fontstyle=\"italic\">28.63<\/v:mn>\n                        <v:mo>\u2009<\/v:mo>\n                     <\/v:math>\n                  <\/jats:inline-formula>\u03bcM) increasing in serum and with abnormally micromorphological changes in kidney. The amount of BUN and creatinine distributed in intestinal tract was positively correlated with those in blood. In impaired renal function rats, the amount of BUN (from <jats:inline-formula>\n                     <z:math xmlns:z=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <z:mn fontstyle=\"italic\">4.26<\/z:mn>\n                        <z:mo>\u00b1<\/z:mo>\n                        <z:mn fontstyle=\"italic\">0.21<\/z:mn>\n                        <z:mo>\u2009<\/z:mo>\n                     <\/z:math>\n                  <\/jats:inline-formula>\u03bcMole to 10.<jats:inline-formula>\n                     <db:math xmlns:db=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <db:mn fontstyle=\"italic\">72<\/db:mn>\n                        <db:mo>\u00b1<\/db:mo>\n                        <db:mn fontstyle=\"italic\">0.55<\/db:mn>\n                        <db:mo>\u2009<\/db:mo>\n                     <\/db:math>\n                  <\/jats:inline-formula>\u03bcMole) and creatinine (from <jats:inline-formula>\n                     <hb:math xmlns:hb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <hb:mn fontstyle=\"italic\">681.4<\/hb:mn>\n                        <hb:mo>\u00b1<\/hb:mo>\n                        <hb:mn fontstyle=\"italic\">23.3<\/hb:mn>\n                     <\/hb:math>\n                  <\/jats:inline-formula> nMole to <jats:inline-formula>\n                     <lb:math xmlns:lb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <lb:mn fontstyle=\"italic\">928.7<\/lb:mn>\n                        <lb:mo>\u00b1<\/lb:mo>\n                        <lb:mn fontstyle=\"italic\">21.3<\/lb:mn>\n                     <\/lb:math>\n                  <\/jats:inline-formula> nMole) distributed in intestinal tract significantly increased. All the results proved that intestinal tract had excretory function compensative for renal function.<\/jats:p>","DOI":"10.1155\/2016\/2695718","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T23:30:17Z","timestamp":1479252617000},"page":"1-7","source":"Crossref","is-referenced-by-count":7,"title":["Excretory Function of Intestinal Tract Enhanced in Kidney Impaired Rats Caused by Adenine"],"prefix":"10.1155","volume":"2016","author":[{"given":"Yu","family":"Yun","sequence":"first","affiliation":[{"name":"Kunming Key Laboratory of Molecular Biology for Sinomedicine, Faculty of Basic Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China"},{"name":"School of Basic Medicine, Kunming Medical University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Gao","sequence":"additional","affiliation":[{"name":"Kunming Key Laboratory of Molecular Biology for Sinomedicine, Faculty of Basic Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[{"name":"Kunming Key Laboratory of Molecular Biology for Sinomedicine, Faculty of Basic Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Gao","sequence":"additional","affiliation":[{"name":"Kunming Key Laboratory of Molecular Biology for Sinomedicine, Faculty of Basic Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlian","family":"Duan","sequence":"additional","affiliation":[{"name":"Kunming Key Laboratory of Molecular Biology for Sinomedicine, Faculty of Basic Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yin","sequence":"additional","affiliation":[{"name":"Kunming Key Laboratory of Molecular Biology for Sinomedicine, Faculty of Basic Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9006-861X","authenticated-orcid":true,"given":"Weigang","family":"Duan","sequence":"additional","affiliation":[{"name":"Kunming Key Laboratory of Molecular Biology for Sinomedicine, Faculty of Basic Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2014.05.018"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/382918"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v5.i6.787"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780080429"},{"issue":"4","key":"5","first-page":"1321","article-title":"Enzymes involved in purine metabolism\u2014a review of histochemical localization and functional implications","volume":"14","author":"Y. 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