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Our results showed that NaHS significantly increased the level of  in rat medullary neurons in a concentration\u2010dependent manner. L\u2010Cysteine and SAM significantly raised the level of  in the medullary neurons while HA and\/or AOAA produced a reversal effect. In addition, L\u2010cysteine and SAM significantly increased but HA and\/or AOAA decreased the production of H<jats:sub>2<\/jats:sub>S in the cultured neurons. The  elevation induced by H<jats:sub>2<\/jats:sub>S was significantly diminished by EGTA\u2010Ca<jats:sup>2+<\/jats:sup>\u2010free solutions, and this elevation was also reduced by nifedipine or nimodipine and mibefradil, suggesting the role of L\u2010type and\/or T\u2010type Ca<jats:sup>2+<\/jats:sup> channels. Moreover, the effect of H<jats:sub>2<\/jats:sub>S on  level in neurons was significantly attenuated by BAPTA\u2010AM and thapsigargin, suggesting the source of Ca<jats:sup>2+<\/jats:sup>. Therefore, we concluded that both exogenous and endogenous H<jats:sub>2<\/jats:sub>S elevates  level in primarily cultured rat medullary neurons via both increasing calcium influx and mobilizing intracellular Ca<jats:sup>2+<\/jats:sup> stores from ER.<\/jats:p>","DOI":"10.1155\/2016\/2735347","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T21:13:45Z","timestamp":1476998025000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hydrogen Sulfide Regulates the [Ca<sup>2+<\/sup>]<sub>i<\/sub> Level in the Primary Medullary 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