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Longevity"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. The study was designed to investigate if H<jats:sub>2<\/jats:sub>S could inhibit high\u2010salt diet\u2010induced renal excessive oxidative stress and kidney injury in Dahl rats. <jats:italic>Methods<\/jats:italic>. Male salt\u2010sensitive Dahl and SD rats were used. Blood pressure (BP), serum creatinine, urea, creatinine clearance rate, and 24\u2010hour urine protein were measured. Renal ultra\u2010 and microstructures were observed. Collagen\u2010I and \u2010III contents the oxidants and antioxidants levels in renal tissue were detected. Keap1\/Nrf2 association and Keap1 s\u2010sulfhydration were detected. <jats:italic>Results<\/jats:italic>. After 8\u2009weeks of high\u2010salt diet, BP was significantly increased, renal function and structure were impaired, and collagen deposition was abundant in renal tissues with increased renal MPO activity, H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>, MDA, GSSG, and <jats:sup>\u2022<\/jats:sup>OH contents, reduced renal T\u2010AOC and GSH contents, CAT, GSH\u2010PX and SOD activity, and SOD expressions in Dahl rats. Furthermore, endogenous H<jats:sub>2<\/jats:sub>S in renal tissues was decreased in Dahl rats. H<jats:sub>2<\/jats:sub>S donor, however, decreased BP, improved renal function and structure, and inhibited collagen excessive deposition in kidney, in association with increased antioxidative activity and reduced oxidative stress in renal tissues. H<jats:sub>2<\/jats:sub>S activated Nrf2 by inducing Keap1 s\u2010sulfhydration and subsequent Keap1\/Nrf2 disassociation. <jats:italic>Conclusions<\/jats:italic>. H<jats:sub>2<\/jats:sub>S protected against high\u2010salt diet\u2010induced renal injury associated with enhanced antioxidant capacity and inhibited renal oxidative stress.<\/jats:p>","DOI":"10.1155\/2016\/2807490","type":"journal-article","created":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T21:02:05Z","timestamp":1451336525000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Hydrogen Sulfide Inhibits High\u2010Salt Diet\u2010Induced Renal Oxidative Stress and Kidney Injury in Dahl 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