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The aim of present study was to determine the effect of obestatin administration on the course of acetic acid\u2010induced colitis in rats. <jats:italic>Materials and Methods<\/jats:italic>. Studies have been performed on male Wistar rats. Colitis was induced by a rectal enema with 3.5% acetic acid solution. Obestatin was administered intraperitoneally twice a day at a dose of 8\u2009nmol\/kg, starting 24\u2009h after the induction of colitis. Seven or 14 days after the induction of colitis, the healing rate of the colon was evaluated. <jats:italic>Results<\/jats:italic>. Treatment with obestatin after induction of colitis accelerated the healing of colonic wall damage and this effect was associated with a decrease in the colitis\u2010evoked increase in mucosal activity of myeloperoxidase and content of interleukin\u20101<jats:italic>\u03b2<\/jats:italic>. Moreover, obestatin administration significantly reversed the colitis\u2010evoked decrease in mucosal blood flow and DNA synthesis. <jats:italic>Conclusion<\/jats:italic>. Administration of exogenous obestatin exhibits therapeutic effects in the course of acetic acid\u2010induced colitis and this effect is related, at least in part, to the obestatin\u2010evoked anti\u2010inflammatory effect, an improvement of local blood flow, and an increase in cell proliferation in colonic mucosa.<\/jats:p>","DOI":"10.1155\/2016\/2834386","type":"journal-article","created":{"date-parts":[[2015,12,20]],"date-time":"2015-12-20T21:00:58Z","timestamp":1450645258000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Obestatin Accelerates the Healing of Acetic Acid\u2010Induced Colitis in Rats"],"prefix":"10.1155","volume":"2016","author":[{"given":"Aleksandra","family":"Matuszyk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Ceranowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zygmunt","family":"Warzecha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Cieszkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Bonior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Jaworek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Ku\u015bnierz-Cabala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Konturek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadeusz","family":"Ambro\u017cy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Dembi\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,20]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1117255"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.109.001958"},{"key":"e_1_2_6_3_2","first-page":"11","article-title":"Peptidyl hormones of endocrine cells origin in the gut\u2014their discovery and physiological relevance","volume":"66","author":"Ceranowicz P.","year":"2015","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000114966"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-1231"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220756"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2004.02.010"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06432"},{"key":"e_1_2_6_9_2","first-page":"561","article-title":"Ghrelin attenuates the development of acute pancreatitis in rats","volume":"54","author":"Dembinski A.","year":"2003","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2006.09.003"},{"key":"e_1_2_6_11_2","first-page":"87","article-title":"Treatment with ghrelin accelerates the healing of acetic acid-induced gastric and duodenal ulcers in rats","volume":"60","author":"Ceranowicz P.","year":"2009","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.882727"},{"key":"e_1_2_6_13_2","first-page":"657","article-title":"Ghrelin accelerates the healing of oral ulcers in non-sialoadenectomized and sialoadenectomized rats","volume":"64","author":"Warzecha Z.","year":"2013","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_6_14_2","first-page":"41","article-title":"Ghrelin ameliorates colonic inflammation. 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