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interleukin 17 (IL-17) in the intestine of mice. IFNT supplementation increased microbial diversity in the jejunum and ileum but decreased microbial diversity in the feces. IFNT supplementation influenced the composition of the intestinal microbiota as follows: (1) decreasing the percentage of<jats:italic>Firmicutes<\/jats:italic>and increasing<jats:italic>Bacteroidetes<\/jats:italic>in the jejunum and ileum; (2) enhancing the percentage of<jats:italic>Firmicutes<\/jats:italic>but decreasing<jats:italic>Bacteroidetes<\/jats:italic>in the colon and feces; (3) decreasing<jats:italic>Lactobacillus<\/jats:italic>in the jejunum and ileum; (4) increasing the percentage of<jats:italic>Blautia<\/jats:italic>,<jats:italic>Bacteroides<\/jats:italic>,<jats:italic>Alloprevotella,<\/jats:italic>and<jats:italic>Lactobacillus<\/jats:italic>in the colon; and (5) increasing the percentage of<jats:italic>Lactobacillus<\/jats:italic>,<jats:italic>Bacteroides<\/jats:italic>, and<jats:italic>Allobaculum<\/jats:italic>, while decreasing<jats:italic>Blautia<\/jats:italic>in the feces. Also, IFNT supplementation decreased the expression of IL-17 in the intestines of normal mice and of an intestinal pathogen infected mice. In conclusion, IFNT supplementation modulates the intestinal microbiota and intestinal IL-17 expression, indicating the applicability of IFNT to treat the intestinal diseases involving IL-17 expression and microbiota.<\/jats:p>","DOI":"10.1155\/2016\/2839232","type":"journal-article","created":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T07:05:16Z","timestamp":1471503916000},"page":"1-9","source":"Crossref","is-referenced-by-count":21,"title":["Interferon Tau Affects Mouse Intestinal Microbiota and Expression of IL-17"],"prefix":"10.1155","volume":"2016","author":[{"given":"Wenkai","family":"Ren","sequence":"first","affiliation":[{"name":"Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Observation and Experiment Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, 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