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According to a two\u2010trial, double\u2010blind, crossover, repeated measures design, 10 young men received either placebo or NAC (20\u2009mg\/kg\/day) immediately after a muscle\u2010damaging exercise protocol (300 eccentric contractions) and for eight consecutive days. Blood sampling and performance assessments were performed before exercise, after exercise, and daily throughout recovery. NAC reduced the decline of reduced glutathione in erythrocytes and the increase of plasma protein carbonyls, serum TAC and erythrocyte oxidized glutathione, and TBARS and catalase activity during recovery thereby altering postexercise redox status. The rise of muscle damage and inflammatory markers (muscle strength, creatine kinase activity, CRP, proinflammatory cytokines, and adhesion molecules) was less pronounced in NAC during the first phase of recovery. The rise of leukocyte and neutrophil count was decreased by NAC after exercise. Results on immune cell subpopulations obtained by flow cytometry indicated that NAC ingestion reduced the exercise\u2010induced rise of total macrophages, HLA<jats:sup>+<\/jats:sup> macrophages, and 11B<jats:sup>+<\/jats:sup> macrophages and abolished the exercise\u2010induced upregulation of B lymphocytes. Natural killer cells declined only in PLA immediately after exercise. These results indicate that thiol\u2010based antioxidant supplementation blunts immune cell mobilisation in response to exercise\u2010induced inflammation suggesting that leukocyte mobilization may be under redox\u2010dependent regulation.<\/jats:p>","DOI":"10.1155\/2016\/2840643","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T23:33:01Z","timestamp":1479252781000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Evidence of a Redox\u2010Dependent Regulation of Immune Responses to Exercise\u2010Induced Inflammation"],"prefix":"10.1155","volume":"2016","author":[{"given":"Alexandra","family":"Sakelliou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8475-8411","authenticated-orcid":false,"given":"Ioannis G.","family":"Fatouros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Athanailidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Tsoukas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Chatzinikolaou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Draganidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios Z.","family":"Jamurtas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Liacos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2126-3251","authenticated-orcid":false,"given":"Ioannis","family":"Papassotiriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Mandalidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimon","family":"Stamatelopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meletios A.","family":"Dimopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asimina","family":"Mitrakou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,15]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00735.2009"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200838110-00005"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.049163"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e3181ac7afa"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200636050-00001"},{"key":"e_1_2_9_6_2","first-page":"R166","article-title":"Acute phase response in exercise. 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