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(DM), <jats:italic>n<\/jats:italic>\u2010hexane (Hex), methanol (MeOH), and water extracts. EA extract was known to have potent antioxidative properties, reducing power, DPPH scavenging activity, and metal ion chelating activity. This study compared these five extracts in terms of their inhibiting effects on three human malignant melanomas: A375, A375.S2, and A2058. MTT assay presented the notion that both EA and DM extracts inhibited melanoma growth but did not affect the viabilities of normal dermal keratinocytes (HaCaT) or fibroblasts. Western blot analyses showed that both EA and DM extracts induced overexpression of caspase proteins in all three melanomas. To determine their roles in melanogenesis, this study analyzed their <jats:italic>in vitro<\/jats:italic> suppressive effects on mushroom tyrosinase. All extracts except for water revealed moderate suppressive effects. None of the extracts affected B16\u2010F10 cells proliferation. EA extract inhibited cellular melanin production whereas DM extract unexpectedly enhanced cellular pigmentation in B16\u2010F10 cells. Data for modulations of microphthalmia\u2010associated transcription factor, tyrosinase, tyrosinase\u2010related protein 1, and tyrosinase\u2010related protein 2 showed that EA extract inhibited protein expression mentioned above whereas DM extract had the opposite effect. 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