{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:31:40Z","timestamp":1780464700040,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T00:00:00Z","timestamp":1471478400000},"content-version":"vor","delay-in-days":230,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"crossref","award":["562248\/2008"],"award-info":[{"award-number":["562248\/2008"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p><jats:italic>Attalea speciosa<\/jats:italic> syn <jats:italic>Orbignya phalerata<\/jats:italic> Mart. (babassu) has been used in the treatment of inflammatory and infectious diseases. <jats:italic>Aim of the study<\/jats:italic>. To investigate the antimicrobial and immunological activity of babassu mesocarp extract (EE). <jats:italic>Material and Methods.<\/jats:italic> The <jats:italic>in vitro<\/jats:italic> antimicrobial activity was evaluated by disk diffusion assay and by determination of the minimum inhibitory concentration (MIC) to <jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Pseudomonas aeruginosa<\/jats:italic>, <jats:italic>Enterococcus faecalis<\/jats:italic>, <jats:italic>Staphylococcus aureus,<\/jats:italic> and methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA). The flavonoids and phenolic acids content were determined by chromatography. The <jats:italic>in vivo<\/jats:italic> assays were performed in Swiss mice submitted to sepsis by cecal ligation and puncture (CLP). The mice received EE subcutaneously (125 or 250\u2009mg\/Kg), 6 hours after the CLP. The number of lymphoid cells was quantified and the cytokines production was determined by ELISA after 12\u2009h. <jats:italic>Results.<\/jats:italic> EE was effective as antimicrobial to <jats:italic>E. faecalis<\/jats:italic>, <jats:italic>S. aureus<\/jats:italic>, and MRSA. EE is rich in phenolic acids, a class of compounds with antimicrobial and immunological activity. An increased survival can be observed in those groups, possibly due to a significant inhibition of TNF\u2010<jats:italic>\u03b1<\/jats:italic> and IL\u20106. <jats:italic>Conclusions.<\/jats:italic> The EE showed specific antimicrobial activity <jats:italic>in vitro<\/jats:italic> and an important antiseptic effect <jats:italic>in vivo<\/jats:italic> possibly due to the antimicrobial and immunomodulatory activity.<\/jats:p>","DOI":"10.1155\/2016\/2859652","type":"journal-article","created":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T06:05:18Z","timestamp":1471586718000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Immunomodulatory and Antimicrobial Activity of Babassu Mesocarp Improves the Survival in Lethal Sepsis"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5867-5583","authenticated-orcid":false,"given":"Elizabeth S. 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