{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:26:05Z","timestamp":1789017965301,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>\n                    Due to the development of praziquantel (PZQ) schistosomes resistant strains, the discovery of new antischistosomal agents is of high priority in research. This work reported the\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    effects of the edible and ornamental pomegranate extracts against\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    . Leaves and stem bark ethanolic extracts of both dried pomegranates were prepared at 100, 300, and 500\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g\/mL for\n                    <jats:italic>in vitro<\/jats:italic>\n                    and 600 and 800\u2009mg\/kg for\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Adult worms\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    in RPMI-1640 medium for\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    infected mice for\n                    <jats:italic>in vivo<\/jats:italic>\n                    tests were obtained from Theodor Bilharz Research Institute, Cairo, Egypt.\n                    <jats:italic>In vitro<\/jats:italic>\n                    activity was manifested by significant coupled worms separation, reduction of motor activity, lethality, and ultrastructural tegumental alterations in adult worms.\n                    <jats:italic>In vivo<\/jats:italic>\n                    activity was manifested revealed by significant reduction of hepatic granulomas number and diameter, decreased number of bilharzial eggs in liver tissues, lowered liver inflammatory infiltration, decreased hepatic fibrosis, and inducible nitric oxide synthase (iNOS) expression. Ethanolic stem bark extract of edible pomegranate exhibited highest antischistosomal activities both\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Therefore, pomegranate showed a good potential to be used as a promising new candidate for the development of new schistosomicidal agents.\n                  <\/jats:p>","DOI":"10.1155\/2016\/2872708","type":"journal-article","created":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T18:26:17Z","timestamp":1479752777000},"page":"1-15","source":"Crossref","is-referenced-by-count":26,"title":["Comparative Evaluation of Anthelmintic Activity of Edible and Ornamental Pomegranate Ethanolic Extracts against\n                    <i>Schistosoma mansoni<\/i>"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8473-8026","authenticated-orcid":true,"given":"Doaa A.","family":"Yones","sequence":"first","affiliation":[{"name":"Parasitology Department, Faculty of Medicine, Assiut University, Assiut 71526, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia M.","family":"Badary","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculty of Medicine, Assiut University, Assiut 71526, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham M. 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