{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:31:08Z","timestamp":1789608668835,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T00:00:00Z","timestamp":1462924800000},"content-version":"vor","delay-in-days":131,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202659"],"award-info":[{"award-number":["81202659"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2014J01373"],"award-info":[{"award-number":["2014J01373"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["ZK1014"],"award-info":[{"award-number":["ZK1014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["DC2013174"],"award-info":[{"award-number":["DC2013174"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202659"],"award-info":[{"award-number":["81202659"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2014J01373"],"award-info":[{"award-number":["2014J01373"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["ZK1014"],"award-info":[{"award-number":["ZK1014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["DC2013174"],"award-info":[{"award-number":["DC2013174"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008865","name":"Scientific Research Start Foundation for New Teacher of Xiamen University","doi-asserted-by":"crossref","award":["81202659"],"award-info":[{"award-number":["81202659"]}],"id":[{"id":"10.13039\/501100008865","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008865","name":"Scientific Research Start Foundation for New Teacher of Xiamen University","doi-asserted-by":"crossref","award":["2014J01373"],"award-info":[{"award-number":["2014J01373"]}],"id":[{"id":"10.13039\/501100008865","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008865","name":"Scientific Research Start Foundation for New Teacher of Xiamen University","doi-asserted-by":"crossref","award":["ZK1014"],"award-info":[{"award-number":["ZK1014"]}],"id":[{"id":"10.13039\/501100008865","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008865","name":"Scientific Research Start Foundation for New Teacher of Xiamen University","doi-asserted-by":"crossref","award":["DC2013174"],"award-info":[{"award-number":["DC2013174"]}],"id":[{"id":"10.13039\/501100008865","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fujian Undergraduate Training Programs for Innovation and Entrepreneurship","award":["81202659"],"award-info":[{"award-number":["81202659"]}]},{"name":"Fujian Undergraduate Training Programs for Innovation and Entrepreneurship","award":["2014J01373"],"award-info":[{"award-number":["2014J01373"]}]},{"name":"Fujian Undergraduate Training Programs for Innovation and Entrepreneurship","award":["ZK1014"],"award-info":[{"award-number":["ZK1014"]}]},{"name":"Fujian Undergraduate Training Programs for Innovation and Entrepreneurship","award":["DC2013174"],"award-info":[{"award-number":["DC2013174"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Chronic liver disease is one of the most common diseases that threaten human health. Effective treatment is still lacking in western medicine. <jats:italic>Semen Persicae<\/jats:italic> (Taoren) and <jats:italic>Flos Carthami<\/jats:italic> (Honghua) are known to relieve acute hepatic injury and inflammation, improve microcirculation, and reduce tissue fiber. The aim of our study is to investigate the potential mechanisms of Taoren\u2010Honghua Herb Pair (THHP) in murine model of chronic liver disease caused by Carbon Tetrachloride (CCl<jats:sub>4<\/jats:sub>). Mice were randomly divided into seven groups: (1) blank, (2) model, (3) control (colchicine, 0.1\u2009mg\/kg), (4) THHP (5.53, 2.67, and 1.33\u2009g\/kg), and (5) Tao Hong Siwu Decoction (THSWD) (8.50\u2009g\/kg). Histological change and microvessels density were examined by microscopy. Hepatic function, serum fibrosis related factors, and hepatic vascular endothelial growth factor (VEGF) were measured with ELISA. VEGF, kinase insert domain\u2010containing receptor (KDR), Flt\u20101, and Akt mRNA expression in hepatic tissue were determined with PCR. Tissues of Akt, pAkt, KDR, and Flt\u20101 were measured with western blotting. Data from this study showed that THHP improved hepatic function and restrained the hepatic inflammation and fibrosis. Its role in inhibiting pathological angiogenesis and hepatic fibrogenesis may be through affecting the angiogenesis\u2010associated VEGF and its upstream and downstream signaling pathways.<\/jats:p>","DOI":"10.1155\/2016\/2974256","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T21:01:23Z","timestamp":1463000483000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Effects of Taoren\u2010Honghua Herb Pair on Pathological Microvessel and Angiogenesis\u2010Associated Signaling Pathway in Mice Model of CCl<sub>4<\/sub>\u2010Induced Chronic Liver Disease"],"prefix":"10.1155","volume":"2016","author":[{"given":"Shengyan","family":"Xi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangxinzi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanjing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,11]]},"reference":[{"key":"e_1_2_9_1_2","first-page":"200","article-title":"Prevention and management of chronic hepatitis B","volume":"5","author":"Bhat M.","year":"2014","journal-title":"International Journal of Preventive Medicine"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161226126"},{"key":"e_1_2_9_3_2","first-page":"141","article-title":"Analysis of modern pharmacologic actions and new application of Carthamus tinctorius L. (Honghua)","volume":"15","author":"Fu P.","year":"2015","journal-title":"World Latest Medicine Information"},{"key":"e_1_2_9_4_2","article-title":"Therapeutic effect analysis of bufonin combining Safflower Injection treating hepatitis and hepatic fibrosis","volume":"18","author":"Chen Y. C.","year":"2007","journal-title":"Hainan Medical Journal"},{"key":"e_1_2_9_5_2","first-page":"660","article-title":"Clinical observation on treatment of chronic hepatitis B caused liver fibrosis by compound peach Kernel softening liver capsule","volume":"22","author":"Li M.","year":"2002","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine"},{"key":"e_1_2_9_6_2","article-title":"Clinical observation of peach kernel and carthamus four substances decoction treating 60 patients with chronic active hepatitis","volume":"17","author":"Bai X.","year":"1996","journal-title":"Shaanxi Journal of Traditional Chinese Medicine"},{"key":"e_1_2_9_7_2","first-page":"655","article-title":"Effects of Peach Kernel and Carthamus four substances decoction combining interferon on hepatic fibrosis patients infected by Hepatitis B virus","volume":"17","author":"Wang S.","year":"2014","journal-title":"Practical Pharmacy and Clinical Remedies"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.05.074"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs20140823"},{"key":"e_1_2_9_10_2","first-page":"444","article-title":"Vascular endothelial growth factor (VEGF)\u2014part 1: in physiology and pathophysiology","volume":"62","author":"Kajdaniuk D.","year":"2011","journal-title":"Endokrynologia Polska"},{"key":"e_1_2_9_11_2","first-page":"107","article-title":"A possible Role for TNF-\u03b1 in coordinating inflammation and angiogenesis in chronic liver disease and hepatocellular carcinoma","volume":"6","author":"Hammam O.","year":"2013","journal-title":"Gastrointestinal Cancer Research"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8278(05)80658-0"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1997.910615.x"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i3.377"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2015.1087040"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.10.056"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000069792"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b15-00325"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.11.038"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02369.x"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq105"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/19420862.2015.1086854"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.13157"},{"key":"e_1_2_9_24_2","first-page":"265","article-title":"Mechanisms and research progress of promoting blood circulation for removing blood stasis herbs in treating hepatic fibrosis","volume":"25","author":"Lei N.","year":"2010","journal-title":"China Journal of Traditional Chinese Medicine and Pharmacy"},{"key":"e_1_2_9_25_2","first-page":"2226","article-title":"Effects of Shenqi Neijin powder on activation and apoptosis of hepatic stellate cells in rats with hepatic fibrosis","volume":"8","author":"Xie H.","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.12.003"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0254-6272(13)60139-9"},{"key":"e_1_2_9_28_2","first-page":"191","article-title":"Research advances in pharmacological function and development and application of Carthamus tinctorius L.","volume":"39","author":"Yi S. Y.","year":"2015","journal-title":"Northern Horticulture"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep11734"},{"key":"e_1_2_9_30_2","first-page":"14","article-title":"The observation about the act on anti-fibrosis of liver with Extractum Semen Persicae (ESP): the research by immunohistochemisty and collagen metabolism","volume":"9","author":"Xu L. M.","year":"1993","journal-title":"Pharmacology and Clinics of Chinese Materia Medica"},{"key":"e_1_2_9_31_2","first-page":"652","article-title":"Effects of Hydroxy safflower yellow A may reduce hepatic fibrosis of experimental rats by action on TGF-\u03b21-CTGF axis","volume":"8","author":"Li H. X.","year":"2014","journal-title":"Chinese Journal of Clinicians"},{"key":"e_1_2_9_32_2","first-page":"46","article-title":"Effects of safflower yellow on hepatic function and correlated serum index of hepatic fibrosis rats","volume":"45","author":"Li W. Z.","year":"2014","journal-title":"Jiangxi Journal of Traditional Chinese Medicine"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.01.061"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2016\/2974256.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2016\/2974256.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2016\/2974256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T01:17:41Z","timestamp":1722907061000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2016\/2974256"}},"subtitle":[],"editor":[{"given":"Yoshiji","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1155\/2016\/2974256"],"URL":"https:\/\/doi.org\/10.1155\/2016\/2974256","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2016-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2974256"}}