{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T09:20:38Z","timestamp":1774862438986,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Interleukin-17 contributes to the pathogenesis of type 1 diabetes mellitus (T1DM) and chronic periodontitis (CP). We analyzed<jats:italic>IL-17A<\/jats:italic>\u2212197A\/G and<jats:italic>IL-17F<\/jats:italic>+7488C\/T polymorphisms in T1DM and CP and determined their associations with IL-17 production and occurrence of periopathogens. Totally 154 controls, 125 T1DM, and 244 CP patients were genotyped using 5\u2032 nuclease<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msup><mml:mrow><mml:mi mathvariant=\"normal\">T<\/mml:mi><mml:mi mathvariant=\"normal\">a<\/mml:mi><mml:mi mathvariant=\"normal\">q<\/mml:mi><mml:mi mathvariant=\"normal\">M<\/mml:mi><mml:mi mathvariant=\"normal\">a<\/mml:mi><mml:mi mathvariant=\"normal\">n<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi mathvariant=\"normal\">\u00ae<\/mml:mi><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>assays. Bacterial colonization was investigated by a DNA-microarray kit. Production of IL-17 after<jats:italic>in vitro<\/jats:italic>stimulation of mononuclear cells by mitogens and bacteria was examined by the Luminex system. Although no differences in the allele\/genotype frequencies between patients with CP and T1DM + CP were found, the<jats:italic>IL-17A<\/jats:italic>\u2212197 A allele increased the risk of T1DM (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>). Levels of HbA1c were significantly elevated in carriers of the A allele in T1DM patients (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>). Production of IL-17 by mononuclear cells of CP patients (unstimulated\/stimulated by<jats:italic>Porphyromonas gingivalis<\/jats:italic>) was associated with<jats:italic>IL-17A<\/jats:italic>A allele (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>).<jats:italic>IL-17A<\/jats:italic>polymorphism increased the number of<jats:italic>Tannerella forsythia<\/jats:italic>and<jats:italic>Treponema denticola<\/jats:italic>in patients with CP and T1DM + CP, respectively (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>).<jats:italic>IL-17A<\/jats:italic>gene variability may influence control of T1DM and the \u201cred complex\u201d bacteria occurrence in patients with CP and T1DM + CP. Our findings demonstrated the functional relevance of the<jats:italic>IL-17A<\/jats:italic>polymorphism with higher IL-17 secretion in individuals with A allele.<\/jats:p>","DOI":"10.1155\/2016\/2979846","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T16:06:38Z","timestamp":1453910798000},"page":"1-9","source":"Crossref","is-referenced-by-count":30,"title":["<i>Interleukin-17A<\/i>Gene Variability in Patients with Type 1 Diabetes Mellitus and Chronic Periodontitis: Its Correlation with IL-17 Levels and the Occurrence of Periodontopathic Bacteria"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0953-3615","authenticated-orcid":true,"given":"Petra","family":"Borilova Linhartova","sequence":"first","affiliation":[{"name":"Clinic of Stomatology, Institutions Shared with St. Anne\u2019s Faculty Hospital, Faculty of Medicine, Masaryk University, 656 91 Brno, Czech Republic"},{"name":"Department of Pathophysiology, 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