{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:03:20Z","timestamp":1740164600386,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Endocrinology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Persistent primary hyperparathyroidism (PHPT) refers to the sustained hypercalcemia state detected within the first six months following parathyroidectomy. When it coexists with severe vitamin D deficiency, the effects on bone can be devastating. We report the case of a 56-year-old woman who was sent to this center because of persistent hyperparathyroidism. Her disease had over 3 years of evolution with nephrolithiasis and hip fracture. Parathyroidectomy was performed in her local unit; however, she continued with hypercalcemia, bone pain, and pathological fractures. On admission, the patient was bedridden with multiple deformations by fractures in thoracic and pelvic members. Blood pressure was 100\/80, heart rate was 86 per minute, and body mass index was 19\u2009kg\/m<jats:sup>2<\/jats:sup>. Calcium was 14\u2009mg\/dL, parathormone 1648\u2009pg\/mL, phosphorus 2.3\u2009mg\/dL, creatinine 2.4\u2009mg\/dL, urea 59\u2009mg\/dL, alkaline phosphatase 1580\u2009U\/L, and vitamin D 4\u2009ng\/mL. She received parenteral treatment of hypercalcemia and replenishment of vitamin D. The second surgical exploration was radioguided by gamma probe. A retroesophageal adenoma of 4\u2009cm was resected.<jats:italic>Conclusion<\/jats:italic>. Persistent hyperparathyroidism with severe vitamin D deficiency can cause catastrophic skeletal bone softening and fractures.<\/jats:p>","DOI":"10.1155\/2016\/3016201","type":"journal-article","created":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T17:00:58Z","timestamp":1469466058000},"page":"1-4","source":"Crossref","is-referenced-by-count":0,"title":["Persistent Primary Hyperparathyroidism, Severe Vitamin D Deficiency, and Multiple Pathological Fractures"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5394-9856","authenticated-orcid":true,"given":"Victoria","family":"Mendoza-Zubieta","sequence":"first","affiliation":[{"name":"Endocrinology Department, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, IMSS, 06720 Mexico City, DF, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Carvallo-Venegas","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad 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