{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:55:26Z","timestamp":1789545326564,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Background and Aims<\/jats:italic>. Upper endoscopy is a valuable tool in the workup of gastrointestinal (GI) complaints. The purpose of this study is to determine cost and yield of taking biopsies in a normal upper GI tract.<jats:italic>Methods<\/jats:italic>. This is a retrospective study where all upper GI biopsies were identified between May 2012 and April 2013, at a tertiary care center. Clinical, procedural, and pathology reports were reviewed to identify patient demographics, procedure information, and pathology diagnosis.<jats:italic>Results<\/jats:italic>. Biopsies of the upper GI tract were taken in 1297 patients with normal upper endoscopies. In patients with normal upper endoscopy, 22% of esophageal, 44% of gastric, and 12% of duodenal biopsies were abnormal. The most frequent abnormality was reflux esophagitis in 16% of esophageal biopsies, chronic gastritis in 23% of gastric biopsies, and increased intraepithelial lymphocytes in 6% of duodenal biopsies. The additional cost for taking biopsies in a normal upper GI tract for a diagnosis of eosinophilic esophagitis was $2963 Canadian (CAD),<jats:italic>H. pylori<\/jats:italic>associated gastritis was $1404 CAD, and celiac disease was $3024 CAD.<jats:italic>Conclusions<\/jats:italic>. The yield of biopsy in normal upper endoscopy varied with location, but the additional expense can be costly and should be tailored to appropriate clinical situations.<\/jats:p>","DOI":"10.1155\/2016\/3026563","type":"journal-article","created":{"date-parts":[[2016,7,10]],"date-time":"2016-07-10T17:00:28Z","timestamp":1468170028000},"page":"1-7","source":"Crossref","is-referenced-by-count":24,"title":["The Utility of Endoscopic Biopsies in Patients with Normal Upper Endoscopy"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5785-0415","authenticated-orcid":true,"given":"Anouar","family":"Teriaky","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Western University and London Health Sciences Centre, London, ON, Canada N6A 5W9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"AlNasser","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of 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