{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:11:45Z","timestamp":1775470305517,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Liaoning Province Education Bureau Project","award":["LZ2015077"],"award-info":[{"award-number":["LZ2015077"]}]},{"name":"Liaoning Province Education Bureau Project","award":["81301388"],"award-info":[{"award-number":["81301388"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["LZ2015077"],"award-info":[{"award-number":["LZ2015077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81301388"],"award-info":[{"award-number":["81301388"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Abnormality of glutathione peroxidase (GPx) is involved in the etiology and pathogenesis of vitiligo. However, the results were controversial.<jats:italic>Aim<\/jats:italic>. The purpose of this meta-analysis is to compare the levels of GPx between vitiligo patients and healthy controls.<jats:italic>Methods.<\/jats:italic>Relevant published articles were searched according to eligibility criteria. A meta-analysis was conducted to pool estimates of the standardized mean difference (SMD) with 95% confidence interval (CI).<jats:italic>Results.<\/jats:italic>Twenty-three studies with a total of 1076 vitiligo patients and 770 healthy controls were included. The pooled meta-analysis showed that patients with vitiligo had equivalent levels of GPx with the healthy controls (SMD = \u22120.47, 95% CI: \u22121.03 to 0.08, and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0<\/mml:mn><mml:mo>.<\/mml:mo><mml:mn fontstyle=\"italic\">095<\/mml:mn><\/mml:math>). Further subgroup analysis showed that the GPx levels of Asian patients or segmental vitiligo patients were, respectively, lower than those of healthy controls (Asian: SMD = \u22120.47, 95% CI: \u22121.08 to 0.14, and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0<\/mml:mn><mml:mn fontstyle=\"italic\">01<\/mml:mn><\/mml:math>; segmental: SMD = \u22123.59, 95% CI: \u22126.38 to \u22120.80, and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.012<\/mml:mn><\/mml:math>). Furthermore, the GPx levels in serum\/plasma were significantly decreased in either stable or active vitiligo patients, comparing to healthy controls (stable: SMD = \u22122.01, 95% CI: \u22123.52 to \u22120.49, and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0<\/mml:mn><mml:mn fontstyle=\"italic\">09<\/mml:mn><\/mml:math>; active: SMD = \u22122.34, 95% CI: \u22124.07 to \u22120.61, and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0<\/mml:mn><mml:mo>.<\/mml:mo><mml:mn fontstyle=\"italic\">008<\/mml:mn><\/mml:math>).<jats:italic>Conclusion<\/jats:italic>. This meta-analysis showed a significant association between low GPx level and vitiligo.<\/jats:p>","DOI":"10.1155\/2016\/3029810","type":"journal-article","created":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T19:08:48Z","timestamp":1461784128000},"page":"1-11","source":"Crossref","is-referenced-by-count":26,"title":["Glutathione Peroxidase Level in Patients with Vitiligo: A Meta-Analysis"],"prefix":"10.1155","volume":"2016","author":[{"given":"Bi-huan","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang 110001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meihui","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang 110001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongqiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department 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