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Patients underwent APT and MT imaging (a single protocol) immediately following the routine MR examination. Single-slice APT\/MT axial imaging was performed at the level of the basal ganglia. APT and MT ratio (MTR) measurements were performed in multiple brain regions of interest (ROIs). Data was statistically analyzed in order to assess for significant differences between the different regions of the brain or correlation with patient gestational age.<jats:italic>Results.<\/jats:italic>A total of 38 neonates were included in the study, with ages ranging from 27 to 41 weeks\u2019 corrected gestational age. There were statistically significant differences in both APT and MTR measurements between the frontal lobes, basal ganglia, and occipital lobes (APT: frontal lobe versus occipital lobe<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.031<\/mml:mn><\/mml:math>and other groups<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.00<\/mml:mn><\/mml:math>; MTR: frontal lobe versus occipital lobe<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.034<\/mml:mn><\/mml:math>and other groups<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.00<\/mml:mn><\/mml:math>). Furthermore, APT and MTR in above brain regions exhibited positive linear correlations with patient gestational age.<jats:italic>Conclusions.<\/jats:italic>APT\/MT imaging can provide valuable information about the process of the neonatal brain development at the molecular level.<\/jats:p>","DOI":"10.1155\/2016\/3052723","type":"journal-article","created":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T17:00:52Z","timestamp":1478192452000},"page":"1-11","source":"Crossref","is-referenced-by-count":12,"title":["Magnetization Transfer and Amide Proton Transfer MRI of Neonatal Brain Development"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7452-0725","authenticated-orcid":true,"given":"Yang","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Radiology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang 110004, 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