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Oxidized tyrosine (O\u2010Tyr) has been widely detected in many consumer protein products. O\u2010Tyr products such as dityrosine (Dityr) and 3\u2010nitrotyrosine (3\u2010NT) are universal biomarkers of protein oxidation and have been demonstrated to be associated with metabolic disorders in biological system. Evaluation of potential intracorporal effects of dietary O\u2010Tyr is important since the mechanism of biological impacts induced by oral oxidized protein products (OPPs) is still limited although we have proved that some dietary OPPs would induce oxidative injury to liver and kidney. <jats:italic>Methods and Results<\/jats:italic>. The present study aimed to investigate the dose\u2010dependent hepatic injury caused by oral O\u2010Tyr in rats. 24\u2010week feeding of O\u2010Tyr enhanced aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities, increased total bilirubin (TBiL) content, and led to oxidative damage in rats liver. Besides, O\u2010Tyr distinctly increased the phosphorylation of p38 and ERK2 MAPKs and enhanced fibrosis\u2010related TGF\u2010<jats:italic>\u03b2<\/jats:italic>1 and Smad2\/3 levels. Higher extracellular matrix (ECM) indexes (ICTP, PIIINP) and histological examination (HE and Masson staining) also supported dose\u2010dependent hepatic fibrosis caused by O\u2010Tyr. <jats:italic>Conclusion<\/jats:italic>. These findings reveal that O\u2010Tyr may induce oxidative damage and hepatic fibrosis via MAPK\/TGF\u2010<jats:italic>\u03b2<\/jats:italic>1 signaling pathway, in which ROS together with malondialdehyde (MDA) and OPPs act as the pivotal mediators.<\/jats:p>","DOI":"10.1155\/2016\/3123294","type":"journal-article","created":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T21:01:12Z","timestamp":1450126872000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["24\u2010Week Exposure to Oxidized Tyrosine Induces Hepatic Fibrosis Involving Activation of the MAPK\/TGF\u2010<i>\u03b2<\/i>1 Signaling Pathway in Sprague\u2010Dawley Rats Model"],"prefix":"10.1155","volume":"2016","author":[{"given":"Zhuqing Leslie","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghui","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowei","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinyi","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,14]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06187.x"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf200277r"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00421.2009"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf800571j"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.62.070193.004053"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf302111j"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2009.01511.x"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6823-10-4"},{"key":"e_1_2_9_9_2","series-title":"I. 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