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The interaction between hepatocytes and sympathetic, parasympathetic, and peptidergic nerve fibers through a variety of neurotransmitters and signaling pathways is recognized as being important in the regulation of hepatocyte function, liver regeneration, and hepatic fibrosis. However, less is known regarding the role of the sympathetic nervous system (SNS) in modulating the hepatic response to oxidative stress. Our aim was to investigate the role of the SNS in healthy and oxidatively stressed liver parenchyma. Mice treated with 6\u2010hydroxydopamine hydrobromide were used to realize chemical sympathectomy. Carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) injection was used to induce oxidative liver injury. Sympathectomized animals were protected from CCl<jats:sub>4<\/jats:sub>induced hepatic lipid peroxidation\u2010mediated cytotoxicity and genotoxicity as assessed by 4\u2010hydroxy\u20102\u2010nonenal levels, morphological features of cell damage, and DNA oxidative damage. Furthermore, sympathectomy modulated hepatic inflammatory response induced by CCl<jats:sub>4<\/jats:sub>\u2010mediated lipid peroxidation. CCl<jats:sub>4<\/jats:sub>induced lipid peroxidation and hepatotoxicity were suppressed by administration of an<jats:italic>\u03b1<\/jats:italic>\u2010adrenergic antagonist. We conclude that the SNS provides a permissive microenvironment for hepatic oxidative stress indicating the possibility that targeting the hepatic<jats:italic>\u03b1<\/jats:italic>\u2010adrenergic signaling could be a viable strategy for improving outcomes in patients with acute hepatic injury.<\/jats:p>","DOI":"10.1155\/2016\/3190617","type":"journal-article","created":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T21:41:34Z","timestamp":1450734094000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Sympathetic Nervous System Control of Carbon Tetrachloride\u2010Induced Oxidative Stress in Liver through<i>\u03b1<\/i>\u2010Adrenergic 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