{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:25:45Z","timestamp":1740173145744,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Medicine"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Bacillary dysentery is a major cause of children\u2019s admission to hospitals. To assess the probiotic and prebiotic (synbiotics) effects in children with dysentery in a randomized clinical trial, 200 children with dysentery were studied in 2 groups: the synbiotic group received 1 tablet\/day of synbiotic for 3\u20135 days and the placebo group received placebo tablets (identical tablet form like probiotics). The standard treatment was administered for all patients. Duration of hospitalization, dysentery, fever, and the weight loss were assessed in each group. It was concluded that there was no significant difference in both groups in the baseline characteristics. The mean duration of dysentery reduced (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>). The mean duration of fever has been significantly reduced in the synbiotic group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn fontstyle=\"italic\">1.64<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">0.87<\/mml:mn><\/mml:math>days) in comparison to the placebo group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mn fontstyle=\"italic\">2.13<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">0.94<\/mml:mn><\/mml:math>days) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>). Average amount of weight loss was significantly lower in the synbiotic group in comparison to that in the placebo group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mn fontstyle=\"italic\">129.5<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">23.388<\/mml:mn><\/mml:math>grams and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mn fontstyle=\"italic\">278<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">28.385<\/mml:mn><\/mml:math>grams, resp.;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>). There was no significant difference in the mean duration of hospitalization in both groups (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>P<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>). The use of synbiotics as an adjuvant therapy to the standard treatment of dysentery significantly reduces the duration of dysentery, fever, and rate of weight losses. The trial is registered with<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.irct.ir\/searchresult.php?id=7647&amp;number=1\">IRCT201109267647N1<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2016\/3194010","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T21:02:22Z","timestamp":1480539742000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of Synbiotics for Treatment of Bacillary Dysentery in Children: A Double-Blind, Randomized, Placebo-Controlled Study"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7824-8132","authenticated-orcid":true,"given":"Manijeh","family":"Kahbazi","sequence":"first","affiliation":[{"name":"Infectious Diseases Research Centre (IDRC), Arak University of Medical Sciences, Arak, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzieh","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Centre (IDRC), Arak University of Medical Sciences, Arak, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nader","family":"Zarinfar","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Centre (IDRC), Arak University of Medical Sciences, Arak, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2724-3534","authenticated-orcid":true,"given":"Mohammad","family":"Arjomandzadegan","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Centre (IDRC), Arak University of Medical Sciences, Arak, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3269-5594","authenticated-orcid":true,"given":"Taha","family":"Fereydouni","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Centre (IDRC), Arak University of Medical Sciences, Arak, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Karimi","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Centre (IDRC), Arak University of Medical Sciences, Arak, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir Reza","family":"Najmi","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Centre (IDRC), Arak University of Medical Sciences, Arak, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"2","key":"1","first-page":"133","volume":"43","year":"2005","journal-title":"Journal of Microbiology"},{"issue":"4","key":"2","first-page":"580","volume":"32","year":"2014","journal-title":"Journal of Health, Population and Nutrition"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3201\/eid1611.090934"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2006.3.432"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.157.6.601-a"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.10.080"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.2174\/1381612053382359"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000239990.35517.bf"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/mpg.0000000000000320"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1600938"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1177\/0009922806289614"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02834.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/00001574-200403000-00017"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1994.tb00011.x"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200209000-00021"},{"journal-title":"Cochrane Database of Systematic Reviews","issue":"2","year":"2004","key":"16"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200110002-00004"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2007.03520.x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.3109\/07853899409147334"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2009.0539"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2005.01228.x"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1177\/0884533608329298"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2014.14022"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128754"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1159\/000087637"},{"journal-title":"The Cochrane Database of Systematic Reviews","issue":"11","year":"2011","key":"26"},{"issue":"5","key":"27","doi-asserted-by":"crossref","first-page":"304","DOI":"10.5694\/j.1326-5377.2008.tb01627.x","volume":"188","year":"2008","journal-title":"The Medical Journal of Australia"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e682"},{"journal-title":"The Cochrane Database of Systematic Reviews","issue":"11","year":"2010","key":"29"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2014.10.009"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2011.11.007"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1080\/08035250152708743"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001264"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1097\/inf.0b013e3181b530bf"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12617"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1097\/mcg.0000000000000007"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200001000-00018"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1815"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1097\/mcc.0b013e32834a4bab"}],"container-title":["Advances in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/amed\/2016\/3194010.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/amed\/2016\/3194010.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/amed\/2016\/3194010.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T16:48:31Z","timestamp":1601225311000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/amed\/2016\/3194010\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":39,"alternative-id":["3194010","3194010"],"URL":"https:\/\/doi.org\/10.1155\/2016\/3194010","relation":{},"ISSN":["2356-6752","2314-758X"],"issn-type":[{"type":"print","value":"2356-6752"},{"type":"electronic","value":"2314-758X"}],"subject":[],"published":{"date-parts":[[2016]]}}}