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Therefore, we aimed to determine the effect of AP1 on autistic\u2010like behaviors, oxidative stress status, and histopathological change of cerebellum in valproic acid (VPA) rat model of autism. VPA was injected on postnatal day (PND) 14 and the animals were orally given AP1 at doses of 50, 100, and 200\u2009mg\u00b7kg<jats:sup>\u22121<\/jats:sup> BW between PND 14 and PND 40. The autism\u2010like behaviors were analyzed via hot\u2010plate, rotarod, elevated plus\u2010maze, learning, memory, and social behavior tests. Oxidative stress and the histological change in the cerebellum were assessed at the end of study. AP1 treated rats improved behaviors in all tests except that in hot\u2010plate test. The improvement of oxidative stress and Purkinje cell loss was also observed in the cerebellum of VPA\u2010treated rats. Our data suggest that AP1 partially reduced autism\u2010like behaviors by improving oxidative stress and Purkinje cell loss. Further research is required to identify the active ingredients in AP1 and gender difference effect.<\/jats:p>","DOI":"10.1155\/2016\/3206561","type":"journal-article","created":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T21:01:11Z","timestamp":1451941271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Autistic\u2010Like Behaviors, Oxidative Stress Status, and Histopathological Changes in Cerebellum of Valproic Acid Rat Model of Autism Are Improved by the Combined Extract of Purple Rice and Silkworm Pupae"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7976-2264","authenticated-orcid":false,"given":"Nartnutda","family":"Morakotsriwan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7383-2348","authenticated-orcid":false,"given":"Jintanaporn","family":"Wattanathorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5330-9421","authenticated-orcid":false,"given":"Woranan","family":"Kirisattayakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kowit","family":"Chaisiwamongkol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"reference":[{"key":"e_1_2_8_1_2","first-page":"167","article-title":"Facts about ASDs. 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