{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:46:45Z","timestamp":1773773205758,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. This research aimed to determine the association between hypoxia-inducible factor-1<jats:italic>\u03b1<\/jats:italic> (HIF-1<jats:italic>\u03b1<\/jats:italic>) expression and laryngeal squamous cell carcinoma clinical stage.<jats:italic> Methods<\/jats:italic>. We retrospectively analyzed paraffin-embedded tissue from 47 laryngeal squamous cell carcinoma (LSCC) patients from 2011 to 2014. HIF-1<jats:italic>\u03b1<\/jats:italic> expression was analyzed by immunohistochemistry using an anti-HIF-1<jats:italic>\u03b1<\/jats:italic> mouse monoclonal antibody. The association between HIF-1<jats:italic>\u03b1<\/jats:italic> expression and clinical stage was analyzed using the chi square test.<jats:italic> Results<\/jats:italic>. The glottis was the predominant site of laryngeal squamous cell carcinoma occurrence, and 43\/47 (91.5%) patients presented at an advanced stage. Of the advanced stage patients, 27\/43 stained positive for HIF-1<jats:italic>\u03b1<\/jats:italic> expression and 16\/43 stained negative. Of the early stage patients, 2\/4 stained positive for HIF-1<jats:italic>\u03b1<\/jats:italic> expression and 2\/4 stained negative. Statistical analysis did not demonstrate significant association of HIF-1<jats:italic>\u03b1<\/jats:italic> expression.<jats:italic> Conclusion<\/jats:italic>. There was no statistically significant association between HIF-1<jats:italic>\u03b1<\/jats:italic> expression and the clinical stage or histological differentiation of LSCC.<\/jats:p>","DOI":"10.1155\/2016\/3215463","type":"journal-article","created":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T17:01:05Z","timestamp":1478019665000},"page":"1-4","source":"Crossref","is-referenced-by-count":3,"title":["Hypoxia-Inducible Factor-1<i>\u03b1<\/i> Expression in Indonesian Laryngeal Squamous Cell Carcinoma Patients"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3363-4563","authenticated-orcid":true,"given":"Agus","family":"Surono","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanto","family":"Priyanto","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sagung Rai","family":"Indrasari","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2008.01.016"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2012.08.006"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2008.01.017"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.08.003"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2007.03.001"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/iub.93"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21983"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1177\/147323001003800618"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.05.025"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-9-432"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00571.x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04891.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2008.06454.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1017\/s1462399409001173"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22214"}],"container-title":["Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2016\/3215463.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2016\/3215463.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2016\/3215463.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T17:01:06Z","timestamp":1478019666000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jo\/2016\/3215463\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":15,"alternative-id":["3215463","3215463"],"URL":"https:\/\/doi.org\/10.1155\/2016\/3215463","relation":{},"ISSN":["1687-8450","1687-8469"],"issn-type":[{"value":"1687-8450","type":"print"},{"value":"1687-8469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}