{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:45:56Z","timestamp":1789757156501,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004612","name":"Funda\u00e7\u00e3o Arauc\u00e1ria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"FINEP","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Analytical Methods in Chemistry"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>17<jats:italic>\u03b1<\/jats:italic>-Ethinyl estradiol (EE2), which is used worldwide in the treatment of some cancers and as a contraceptive, is often found in aquatic systems and is considered a pharmaceutically active compound (PhACs) in the environment. Current methods for the determination of this compound, such as chromatography, are expensive and lengthy and require large amounts of toxic organic solvents. In this work, a voltammetric procedure is developed and validated as a screening tool for detecting EE2 in water samples without prior extraction, clean-up, or derivatization steps. Application of the method we elaborate here to EE2 analysis is unprecedented. EE2 detection was carried out using differential pulse adsorptive cathodic stripping voltammetry (DP AdCSV) with a hanging mercury drop electrode (HMDE) in pH 7.0 Britton-Robinson buffer. The electrochemical process of EE2 reduction was investigated by cyclic voltammetry at different scan rates. Electroreduction of the hormone on a mercury electrode exhibited a peak at \u2212<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn fontstyle=\"italic\">1.16<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">0.02<\/mml:mn><\/mml:math>\u2009V versus Ag\/AgCl. The experimental parameters were as follows: \u22120.7\u2009V accumulation potential, 150\u2009s accumulation time, and 60\u2009mV\u2009s<jats:sup>\u22121<\/jats:sup>scan rate. The limit of detection was 0.49\u2009<jats:italic>\u03bc<\/jats:italic>g\u2009L<jats:sup>\u22121<\/jats:sup>for a preconcentration time of 150\u2009s. Relative standard deviations were less than 13%. The method was applied to the detection of EE2 in water samples with recoveries ranging from 93.7 to 102.5%.<\/jats:p>","DOI":"10.1155\/2016\/3217080","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T21:04:55Z","timestamp":1474491895000},"page":"1-7","source":"Crossref","is-referenced-by-count":17,"title":["Rapid Screening Method for Detecting Ethinyl Estradiol in Natural Water Employing Voltammetry"],"prefix":"10.1155","volume":"2016","author":[{"given":"Chalder Nogueira","family":"Nunes","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Estadual do Centro-Oeste, 85040-080 Guarapuava, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Ely","family":"Pauluk","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Estadual do Centro-Oeste, 85040-080 Guarapuava, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lurdes","family":"Felsner","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Estadual do Centro-Oeste, 85040-080 Guarapuava, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Eg\u00e9a dos Anjos","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Estadual de Ponta Grossa, 84030-900 Ponta Grossa, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1485-1063","authenticated-orcid":true,"given":"Sueli P\u00e9rcio","family":"Quin\u00e1ia","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Estadual do Centro-Oeste, 85040-080 Guarapuava, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2012.02.033"},{"issue":"11-12","key":"3","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1351\/pac200375111859","volume":"75","year":"2003","journal-title":"Pure and Applied Chemistry"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2015.06.016"},{"issue":"4","key":"5","first-page":"1089","volume":"21","year":"2012","journal-title":"Polish Journal of Environmental Studies"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2015.09.005"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2016.01.008"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2014.11.004"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioelechem.2006.10.001"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2005.07.024"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2009.10.031"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-015-8792-1"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2012.11.037"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.electacta.2015.09.057"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2015.04.043"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.electacta.2013.10.024"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-40422011000300022"},{"key":"18","year":"2010"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1214\/aoms\/1177729885"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1080\/00401706.1969.10490657"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1590\/s0100-40422005000300017"},{"key":"23","first-page":"129","volume":"13","year":"2003","journal-title":"Pesticidas: Revista de Ecotoxicologia e Meio Ambiente"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-40422004000500017"}],"container-title":["Journal of Analytical Methods in Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jamc\/2016\/3217080.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jamc\/2016\/3217080.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jamc\/2016\/3217080.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T05:54:23Z","timestamp":1589694863000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jamc\/2016\/3217080\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":22,"alternative-id":["3217080","3217080"],"URL":"https:\/\/doi.org\/10.1155\/2016\/3217080","relation":{},"ISSN":["2090-8865","2090-8873"],"issn-type":[{"value":"2090-8865","type":"print"},{"value":"2090-8873","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}