{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:54:50Z","timestamp":1740174890696,"version":"3.37.3"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61374147","61004083","61203103","N150402001","N120404014"],"award-info":[{"award-number":["61374147","61004083","61203103","N150402001","N120404014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61374147","61004083","61203103","N150402001","N120404014"],"award-info":[{"award-number":["61374147","61004083","61203103","N150402001","N120404014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61374147","61004083","61203103","N150402001","N120404014"],"award-info":[{"award-number":["61374147","61004083","61203103","N150402001","N120404014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["61374147","61004083","61203103","N150402001","N120404014"],"award-info":[{"award-number":["61374147","61004083","61203103","N150402001","N120404014"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["61374147","61004083","61203103","N150402001","N120404014"],"award-info":[{"award-number":["61374147","61004083","61203103","N150402001","N120404014"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scientific Programming"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Optimized control of the drug extraction production process (DEPP) aims to reduce production costs and improve economic benefit while meeting quality requirements. However, optimization of DEPP is hampered by model uncertainty. Thus, in this paper, a strategy that considers model uncertainty is proposed. Mechanistic modeling of DEPP is first discussed in the context of previous work. The predictive model used for optimization is then developed by simplifying the mechanism. Optimization for a single extraction process is first implemented, but this is found to lead to serious wastage of herbs. Hence, the optimization of a multiextraction process is then conducted. To manage the uncertainty in the model, a data-driven iterative learning control method is introduced to improve the economic benefit by adjusting the operating variables. Finally, fuzzy parameter adjustment is adopted to enhance the convergence rate of the algorithm. The effectiveness of the proposed modeling and optimization strategy is validated through a series of simulations.<\/jats:p>","DOI":"10.1155\/2016\/3279423","type":"journal-article","created":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T21:04:44Z","timestamp":1480626284000},"page":"1-15","source":"Crossref","is-referenced-by-count":1,"title":["Modeling and Optimization of the Drug Extraction Production Process"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8303-529X","authenticated-orcid":true,"given":"Dakuo","family":"He","sequence":"first","affiliation":[{"name":"College of Information Science and Engineering, Northeastern University, Shenyang, Liaoning 110004, China"},{"name":"State Key Laboratory of Synthetical Automation for Process Industries, Northeastern University, Shenyang 110004, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6230-980X","authenticated-orcid":true,"given":"Zhengsong","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Information Science and Engineering, Northeastern University, Shenyang, Liaoning 110004, China"}]},{"given":"Le","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Information Science and Engineering, Northeastern University, Shenyang, Liaoning 110004, China"}]},{"given":"Tongshan","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Information Science and Engineering, Northeastern University, Shenyang, Liaoning 110004, China"}]},{"given":"Yao","family":"Yao","sequence":"additional","affiliation":[{"name":"College of Information Science and Engineering, Northeastern University, Shenyang, Liaoning 110004, China"}]},{"given":"Zhizhong","family":"Mao","sequence":"additional","affiliation":[{"name":"College of Information Science and Engineering, Northeastern University, Shenyang, Liaoning 110004, China"},{"name":"State Key Laboratory of Synthetical Automation for Process Industries, Northeastern University, Shenyang 110004, China"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1021\/ac9508199"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(99)00071-0"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s0098-1354(00)00411-7"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(02)01225-6"},{"issue":"8","key":"5","first-page":"723","volume":"29","year":"2004","journal-title":"China Journal of Chinese Materia Medica"},{"issue":"8","key":"6","first-page":"59","volume":"34","year":"2006","journal-title":"Chemical Engineering"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/aic.14165"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s11947-012-0975-6"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1296.157722"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.05.031"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2012.03.008"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.09.110"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.09.050"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/s0009-2509(02)00145-8"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/bf02699122"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114300"},{"year":"2006","key":"17"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.compchemeng.2011.02.012"},{"issue":"4","key":"19","first-page":"399","volume":"5","year":"2005","journal-title":"The Chinese Journal of Process Engineering"},{"issue":"11","key":"20","first-page":"36","volume":"34","year":"2006","journal-title":"Chemical Engineering"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1080\/10408390500526514"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1021\/ie960354s"},{"issue":"1","key":"24","first-page":"11","volume":"23","year":"2001","journal-title":"Chinese Traditional Patent Medicine"},{"year":"2011","key":"25"},{"issue":"8","key":"26","first-page":"1942","volume":"4","year":"1995","journal-title":"IEEE International Conference on Neural Networks"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.renene.2015.08.060"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.renene.2015.07.026"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1109\/tcyb.2014.2387067"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemolab.2012.11.016"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemolab.2005.03.003"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprocont.2004.04.005"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.compchemeng.2013.05.027"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.automatica.2013.04.039"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.nonrwa.2012.07.017"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprocont.2012.08.001"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfranklin.2015.03.014"},{"issue":"8","key":"38","first-page":"1001","volume":"29","year":"2012","journal-title":"Control Theory and Applications"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1002\/aic.690010222"},{"year":"2002","key":"40"},{"issue":"12","key":"23","first-page":"2990","volume":"59","year":"2008","journal-title":"Journal of Chemical Industry and Engineering"},{"issue":"10","key":"41","first-page":"115","volume":"36","year":"2010","journal-title":"Technology of Water Treatment"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.04.024"}],"container-title":["Scientific Programming"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/sp\/2016\/3279423.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/sp\/2016\/3279423.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/sp\/2016\/3279423.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T10:47:35Z","timestamp":1589712455000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/sp\/2016\/3279423\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":42,"alternative-id":["3279423","3279423"],"URL":"https:\/\/doi.org\/10.1155\/2016\/3279423","relation":{},"ISSN":["1058-9244","1875-919X"],"issn-type":[{"type":"print","value":"1058-9244"},{"type":"electronic","value":"1875-919X"}],"subject":[],"published":{"date-parts":[[2016]]}}}