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Active components of <jats:italic>S. miltiorrhiza<\/jats:italic> depside salt and aspirin\u2019s related genes were identified via the STITCH4.0 and GeneCards Database. A text search engine (Agilent Literature Search 2.71) and MCODE software were applied to construct network and divide modules, respectively. Finally, 32, 2, and 28 overlapping genes, modules, and pathways were identified between active components of <jats:italic>S. miltiorrhiza<\/jats:italic> depside salt and aspirin. A multidimensional framework of drug network showed that two networks reflected commonly in human aortic endothelial cells and atherosclerosis process. Aspirin plays a more important role in metabolism, such as the well\u2010known AA metabolism pathway and other lipid or carbohydrate metabolism pathways. <jats:italic>S. miltiorrhiza<\/jats:italic> depside salt still plays a regulatory role in type II diabetes mellitus, insulin resistance, and adipocytokine signaling pathway. Therefore, this study suggests that aspirin combined with <jats:italic>S. miltiorrhiza<\/jats:italic> depside salt may be more efficient in treatment of CHD patients, especially those with diabetes mellitus or hyperlipidemia. 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