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The involvement of neuronal SNARE proteins reveals the role of the neurotransmitter release in expressing the opioid actions. The present study was designed to determine the effect of the alkaloid extract of<jats:italic>Erythroxylum cuneatum<\/jats:italic>(<jats:italic>E. cuneatum<\/jats:italic>) against chronic morphine and the influences of<jats:italic>E. cuneatum<\/jats:italic>on neurotransmission processes observed<jats:italic>in vitro<\/jats:italic>. The human neuroblastoma cell line, SK\u2010N\u2010SH, was treated with the morphine, methadone, or<jats:italic>E. cuneatum<\/jats:italic>. The cell lysates were collected and tested for<jats:italic>\u03b1<\/jats:italic>\u2010synuclein, calmodulin, vesicle\u2010associated membrane protein 2 (VAMP 2), and synaptotagmin 1. The extract of<jats:italic>E. cuneatum<\/jats:italic>was observed to upregulate the decreased expression of dependence proteins, namely,<jats:italic>\u03b1<\/jats:italic>\u2010synuclein and calmodulin. The effects were comparable to methadone and control. The expressions of VAMP 2 and synaptotagmin 1 were normalised by the plant and methadone. The extract of<jats:italic>E. cuneatum<\/jats:italic>was postulated to treat dependence symptoms after chronic morphine and improve the soluble N\u2010ethylmaleimide\u2010sensitive factor activating protein receptor (SNARE) protein involved in synaptic vesicle after.<\/jats:p>","DOI":"10.1155\/2016\/3517209","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T22:09:49Z","timestamp":1479334189000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Morphine Antidependence of<i>Erythroxylum cuneatum<\/i>(Miq.) 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