{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:13:18Z","timestamp":1778695998101,"version":"3.51.4"},"reference-count":34,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Nutrition and Metabolism"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Some botanicals have been reported to possess antioxidative activities acting as scavengers of free radicals rendering their usage in herbal medicine. Here we describe the potential use of \u201cSAL,\u201d a standardized blend comprised of three extracts from<jats:italic>Schisandra chinensis<\/jats:italic>,<jats:italic>Artemisia capillaris<\/jats:italic>, and<jats:italic>Aloe barbadensis<\/jats:italic>, in mitigating chemically induced acute liver toxicities. Acetaminophen and carbon tetrachloride induced acute liver toxicity models in mice were utilized. Hepatic functional tests from serum collected at T24 and hepatic glutathione and superoxide dismutases from liver homogenates were evaluated. Histopathology analysis and merit of blending 3 standardized extracts were also confirmed. Statistically significant and dose-correlated inhibitions in serum ALT ranging from 52.5% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.004<\/mml:mn><\/mml:math>) to 34.6% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>) in the APAP and 46.3% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>) to 29.9% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.02<\/mml:mn><\/mml:math>) in the CCl<jats:sub>4<\/jats:sub>models were observed for SAL administered at doses of 400\u2013250\u2009mg\/kg. Moreover, SAL resulted in up to 60.6% and 80.2% reductions in serums AST and bile acid, respectively. The composition replenished depleted hepatic glutathione in association with an increase of hepatic superoxide dismutase. Unexpected synergistic protection from liver damage was also observed. Therefore, the composition SAL could be potentially utilized as an effective hepatic-detoxification agent for the protection from liver damage.<\/jats:p>","DOI":"10.1155\/2016\/3530971","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T21:00:46Z","timestamp":1458075646000},"page":"1-10","source":"Crossref","is-referenced-by-count":7,"title":["Hepatoprotective Activity of Herbal Composition SAL, a Standardize Blend Comprised of<i>Schisandra chinensis<\/i>,<i>Artemisia capillaris<\/i>, and<i>Aloe barbadensis<\/i>"],"prefix":"10.1155","volume":"2016","author":[{"given":"Mesfin","family":"Yimam","sequence":"first","affiliation":[{"name":"Unigen, Inc., 3005 1st Avenue, Seattle, WA 98121, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Jiao","sequence":"additional","affiliation":[{"name":"Unigen, Inc., 3005 1st Avenue, Seattle, WA 98121, 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