{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:30:39Z","timestamp":1793781039161,"version":"4.6.1"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004054","name":"King Abdulaziz University of Saudi Arabia","doi-asserted-by":"publisher","award":["503-130-1434"],"award-info":[{"award-number":["503-130-1434"]}],"id":[{"id":"10.13039\/501100004054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>\n                    Gastric ulcers are among the most common diseases affecting humans. This study aimed at investigating the gastroprotective effects of manuka honey against ethanol\u2010induced gastric ulcers in rats. The mechanism by which honey exerts its antiulcer potential was elucidated. Four groups of rats were used: control, ethanol (ulcer), omeprazole, and manuka honey. Stomachs were examined macroscopically for hemorrhagic lesions in the glandular mucosa, histopathological changes, and glycoprotein detection. The effects of oxidative stress were investigated using the following indicators: gastric mucosal nitric oxide (NO), reduced glutathione (GSH), lipid peroxide (MDA, measured as malondialdehyde) glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase. Plasma tumour necrosis factor\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , interleukin\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    , and IL\u20106 were also measured. Manuka honey significantly decreased the ulcer index, completely protected the mucosa from lesions, and preserved gastric mucosal glycoprotein. It significantly increased gastric mucosal levels of NO, GSH, GPx, and SOD. Manuka honey also decreased gastric mucosal MDA and plasma TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    , and IL\u20106 concentrations. In conclusion, manuka honey likely exerted its antiulcer, effect by keeping enzymatic (GPx and SOD) and nonenzymatic (GSH and NO) antioxidants as well as inflammatory cytokines (TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    , and IL\u20106) in a reduced form, inhibited lipid peroxidation (MDA), and preserved mucous glycoproteins levels.\n                  <\/jats:p>","DOI":"10.1155\/2016\/3643824","type":"journal-article","created":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T16:35:13Z","timestamp":1449592513000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":145,"title":["Antioxidant, Anti\u2010inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats"],"prefix":"10.1155","volume":"2016","author":[{"given":"Saad B.","family":"Almasaudi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagla A.","family":"El-Shitany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aymn T.","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umama A.","family":"Abdel-dayem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soad S.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soad K.","family":"Al Jaouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7512-8787","authenticated-orcid":false,"given":"Steve","family":"Harakeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,7]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0091-2182(97)00031-1"},{"key":"e_1_2_7_2_2","volume-title":"Pharmacology","author":"Rang H. 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A. Mechanism of omeprazole induced-gastric protection against ethanol-induced gastric injury in rats: role of mucosal nitric oxide and apoptotic cell death Proceedings of the 1st International Egyptian-Jordanian Conference on Biotechnology and Sustainable Development: Current Status and Future Scenarios 2006 Cairo Egypt 183\u2013194."},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.5560\/znc.2012.67c0047"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1998.0420"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1023\/a:1018859824926"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/bf00936440"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00361.2003"},{"key":"e_1_2_7_25_2","first-page":"214","article-title":"Tissue sulfhydryl groups","volume":"74","author":"Ellman G. 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