{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:32:13Z","timestamp":1777599133019,"version":"3.51.4"},"reference-count":9,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["DPI2015-69948-R"],"award-info":[{"award-number":["DPI2015-69948-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of A Coruna","award":["DPI2015-69948-R"],"award-info":[{"award-number":["DPI2015-69948-R"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Conjunctival hyperemia or conjunctival redness is a symptom that can be associated with a broad group of ocular diseases. Its levels of severity are represented by standard photographic charts that are visually compared with the patient\u2019s eye. This way, the hyperemia diagnosis becomes a nonrepeatable task that depends on the experience of the grader. To solve this problem, we have proposed a computer-aided methodology that comprises three main stages: the segmentation of the conjunctiva, the extraction of features in this region based on colour and the presence of blood vessels, and, finally, the transformation of these features into grading scale values by means of regression techniques. However, the conjunctival segmentation can be slightly inaccurate mainly due to illumination issues. In this work, we analyse the relevance of different features with respect to their location within the conjunctiva in order to delimit a reliable region of interest for the grading. The results show that the automatic procedure behaves like an expert using only a limited region of interest within the conjunctiva.<\/jats:p>","DOI":"10.1155\/2016\/3695014","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T21:07:42Z","timestamp":1482181662000},"page":"1-9","source":"Crossref","is-referenced-by-count":9,"title":["Defining the Optimal Region of Interest for Hyperemia Grading in the Bulbar Conjunctiva"],"prefix":"10.1155","volume":"2016","author":[{"given":"Mar\u00eda Luisa","family":"S\u00e1nchez Brea","sequence":"first","affiliation":[{"name":"VARPA Group, Department of Computer Science, University of A Coruna, A Coruna, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0961-2057","authenticated-orcid":true,"given":"Noelia","family":"Barreira Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"VARPA Group, Department of Computer Science, University of A Coruna, A Coruna, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Mosquera Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Artificial Vision Group, Department of Electronics and Computer Science, University of Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharine","family":"Evans","sequence":"additional","affiliation":[{"name":"School of Optometry and Vision Sciences, Cardiff University, Wales, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Pena-Verdeal","sequence":"additional","affiliation":[{"name":"Optometry Group, Department of Applied Physics, University of Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"9"},{"issue":"6","key":"7","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1128\/AEM.62.6.1908-1912.1996","volume":"62","year":"1996","journal-title":"Applied and Environmental Microbiology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02143-13"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1023\/a:1020538429009"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/bf00879755"},{"issue":"2","key":"12","first-page":"130","volume":"15","year":"2002","journal-title":"Biomedical and Environmental Sciences"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro842"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.12.8649-8655.2005"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-016-6128-0"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2016\/3695014.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2016\/3695014.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2016\/3695014.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T02:50:59Z","timestamp":1601261459000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2016\/3695014\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":9,"alternative-id":["3695014","3695014"],"URL":"https:\/\/doi.org\/10.1155\/2016\/3695014","relation":{},"ISSN":["1748-670X","1748-6718"],"issn-type":[{"value":"1748-670X","type":"print"},{"value":"1748-6718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}