{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T14:26:23Z","timestamp":1777731983102,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To report the early outcomes of iontophoresis-assisted corneal collagen cross-linking procedure with epithelial debridement (I-SCXL).<jats:italic>Methods<\/jats:italic>. Twenty eyes of twenty patients with progressive keratoconus were included in this prospective clinical study. Best spectacle corrected visual acuity (BSCVA), sphere and cylinder refraction, corneal topography, Scheimpflug tomography, aberrometry, anterior segment optical coherence tomography (AS-OCT), and endothelial cell count were assessed at baseline and at 1, 3, and 6 months of follow-up. The parameters considered to establish keratoconus progression were always proven with differential maps as change in curvature in the cone area of at least 1 diopter obtained with an instantaneous map.<jats:italic>Results<\/jats:italic>. Functional parameters showed a significant improvement (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn mathvariant=\"normal\">0.05<\/mml:mn><\/mml:math>) of BSCVA after 3 and 6 months of follow-up. Morphological parameters indicated stabilization of the corneal ectasia during the follow-up; however, a positive trend was noted with a mean flattening of 1.73\u2009D. Minimum pachymetry values showed thinning that remained constant after the treatment. The demarcation line was clearly visible in all patients, reaching a depth of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn mathvariant=\"normal\">308.2<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn mathvariant=\"normal\">37.74<\/mml:mn><\/mml:math>\u2009<jats:italic>\u03bc<\/jats:italic>m. None of the patients had continuous progression of keratoconus or had to repeat cross-linking procedures. Endothelial cell counts did not change significantly (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn mathvariant=\"normal\">0.05<\/mml:mn><\/mml:math>).<jats:italic>Conclusion<\/jats:italic>. The early results indicate that the I-SCXL may be able to reduce the treatment time and improve the riboflavin diffusion.<\/jats:p>","DOI":"10.1155\/2016\/3720517","type":"journal-article","created":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T08:16:16Z","timestamp":1469780176000},"page":"1-5","source":"Crossref","is-referenced-by-count":19,"title":["Iontophoresis-Assisted Corneal Collagen Cross-Linking with Epithelial Debridement: Preliminary Results"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3864-8246","authenticated-orcid":true,"given":"Paolo","family":"Vinciguerra","sequence":"first","affiliation":[{"name":"Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Italy"},{"name":"Humanitas University, Rozzano, 20089 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5148-7643","authenticated-orcid":true,"given":"Vito","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Corneal and External Eye Diseases, St. Paul\u2019s Eye Unit, Royal Liverpool University Hospital, Liverpool L7 8XP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8491-6574","authenticated-orcid":true,"given":"Pietro","family":"Rosetta","sequence":"additional","affiliation":[{"name":"Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela F.","family":"Legrottaglie","sequence":"additional","affiliation":[{"name":"Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6851-5527","authenticated-orcid":true,"given":"Magdalena","family":"Kubrak-Kisza","sequence":"additional","affiliation":[{"name":"Department and Clinic of Ophthalmology, Wroc\u0142aw Medical University, 50-556 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1334-0974","authenticated-orcid":true,"given":"Claudio","family":"Azzolini","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Division of Ophthalmology, University of Insubria, 21100 Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2280-9981","authenticated-orcid":true,"given":"Riccardo","family":"Vinciguerra","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Division of Ophthalmology, University of Insubria, 21100 Varese, Italy"},{"name":"Department of Ophthalmology, Humanitas Mater Domini, Via Gerenzano 2, 21053 Castellanza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(80)80027-3"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.22.5.333.5491"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.10.021"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(02)02220-1"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.09.048"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.12.039"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.11.018"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3928\/1081597x-20130509-01"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/404587"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13363"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12595"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20141021-06"},{"key":"13","volume":"54, article 4072","year":"2013","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"3","key":"14","first-page":"S374","volume":"18","year":"2002","journal-title":"Journal of Refractive Surgery"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.10.023"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12595"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(94)31313-3"},{"key":"18","first-page":"329","volume":"7","year":"2013","journal-title":"Clinical Ophthalmology"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/604731"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.2.7.6"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2013.12.012"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-11409"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2013.10.029"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000225720.38748.58"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2015.04.033"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.3928\/1081597x-20160204-03"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.09.010"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.07.005"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.3928\/1081597x-20141218-04"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/3720517.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/3720517.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/3720517.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T15:11:23Z","timestamp":1471533083000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2016\/3720517\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":29,"alternative-id":["3720517","3720517"],"URL":"https:\/\/doi.org\/10.1155\/2016\/3720517","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}