{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:37:37Z","timestamp":1789915057178,"version":"4.0.1"},"reference-count":14,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"A rapid IgM-detection immunochromatographic test (WITNESS\u00ae Lepto, Zoetis) has recently become available to identify acute canine leptospirosis at the point of care. Diagnostic sensitivity and specificity of the test were evaluated by comparison with the microscopic agglutination assay (MAT), using a positive cut-off titer of \u2265800. Banked serum samples from dogs exhibiting clinical signs and suspected leptospirosis were selected to form three groups based on MAT titer: (1) positive (n<\/mml:mi>=<\/mml:mo>50<\/mml:mn><\/mml:math>); (2) borderline (n<\/mml:mi>=<\/mml:mo>35<\/mml:mn><\/mml:math>); and (3) negative (n<\/mml:mi>=<\/mml:mo>50<\/mml:mn><\/mml:math>). Using an analysis to weight group sizes to reflect French prevalence, the sensitivity and specificity were 98% and 93.5% (88.2% unweighted), respectively. This test rapidly identifies cases of acute canine leptospirosis with high levels of sensitivity and specificity with no interference from previous vaccination.<\/jats:p>","DOI":"10.1155\/2016\/3760191","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T21:01:39Z","timestamp":1458853299000},"page":"1-3","source":"Crossref","is-referenced-by-count":20,"title":["A Rapid In-Clinic Test Detects Acute Leptospirosis in Dogs with High Sensitivity and Specificity"],"prefix":"10.1155","volume":"2016","author":[{"given":"Angeli","family":"Kodjo","sequence":"first","affiliation":[{"name":"Laboratoire des Leptospires, VetAgro Sup, Campus Veterinaire de Lyon, 1 avenue Bourgelat, 69280 Marcy l\u2019Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Calleja","sequence":"additional","affiliation":[{"name":"Zoetis Global Diagnostics, 100 Campus Drive, Florham Park, NJ 07932, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Loenser","sequence":"additional","affiliation":[{"name":"Zoetis Global Diagnostics, 100 Campus Drive, Florham Park, NJ 07932, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Lin","sequence":"additional","affiliation":[{"name":"Zoetis Veterinary Medicine Research & Development, Hoge Wei 10, 1930 Zaventem, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Lizer","sequence":"additional","affiliation":[{"name":"Zoetis Veterinary Medicine Research & Development, 333 Portage Street, Kalamazoo, MI 49007, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cair.2004.08.001"},{"key":"1","doi-asserted-by":"publisher","DOI":"10.1590\/s0102-311x2005000600046"},{"issue":"2","key":"2","first-page":"178","volume":"4","year":"2003","journal-title":"Veterinary Therapeutics"},{"issue":"3","key":"3","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2460\/javma.237.3.293","volume":"237","year":"2010","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2007.00324.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2012.03.015"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2012.10.002"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.2460\/javma.230.11.1657"},{"key":"5","year":"1939"},{"issue":"1007","key":"6","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1098\/rspa.1946.0056","volume":"186","year":"1946","journal-title":"Proceedings of the Royal Society of London, Series A: Mathematical and Physical Sciences"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2010.0654.x"},{"issue":"8","key":"14","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1128\/JCM.35.8.1938-1942.1997","volume":"35","year":"1997","journal-title":"Journal of Clinical Microbiology"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12328"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.2.296-326.2001"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/3760191.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/3760191.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/3760191.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T04:48:51Z","timestamp":1655354931000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2016\/3760191\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":14,"alternative-id":["3760191","3760191"],"URL":"https:\/\/doi.org\/10.1155\/2016\/3760191","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}