{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:13Z","timestamp":1787017693092,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T00:00:00Z","timestamp":1454889600000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>\n                    The study aims to evaluate analgesic and antipyretic activities of the methanol extract and its different fractions from root of\n                    <jats:italic>Schoenoplectus grossus<\/jats:italic>\n                    using acetic acid induced writhing and radiant heat tail flick method of pain models in mice and yeast induced pyrexia in rats at the doses of 400 and 200\u2009mg\/kg. In acetic acid writhing test, the methanol extract, petroleum ether, and carbon tetrachloride fractions produced significant (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001 and\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05) inhibition of writhing responses in dose dependent manner. The methanol extract at 400 and 200\u2009mg\/kg being more protective with 54% and 45.45% of inhibition compared to diclofenac sodium of 56% followed by petroleum ether fractions of 49.69% and 39.39% at the same doses. The extracts did not produce any significant antinociceptive activity in tail flick test except standard morphine. When studied on yeast induced pyrexia, methanol and petroleum ether fractions significantly lowered the rectal temperature time dependently in a manner similar to standard drug paracetamol and distinctly more significant (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001) after second hour. These findings suggest that the root extracts of\n                    <jats:italic>S. grossus<\/jats:italic>\n                    possess significant peripherally acting analgesic potential and antipyretic property. The phytochemical screening showed the presence of flavonoids, alkaloids, and tannins.\n                  <\/jats:p>","DOI":"10.1155\/2016\/3820704","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T16:00:55Z","timestamp":1454947255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Analgesic and Antipyretic Activities of Methanol Extract and Its Fraction from the Root of\n                    <i>Schoenoplectus grossus<\/i>"],"prefix":"10.1155","volume":"2016","author":[{"given":"Nirmal Kumar","family":"Subedi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M. Abdur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Ahsanul","family":"Akbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,8]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.2165\/11633470-000000000-00000"},{"key":"e_1_2_8_2_2","first-page":"804","article-title":"A metaanalysis of severe upper gastrointestinal complications of nonsteroidal antiinflammatory drugs","volume":"29","author":"Ofman J. J.","year":"2002","journal-title":"The Journal of Rheumatology"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38456.398507.8f"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(04)17514-4"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(04)16299-5"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.330.7489.440"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2008\/11\/S105"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1586\/14737167.6.5.591"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2009.161"},{"key":"e_1_2_8_10_2","volume-title":"The World Medicine Situation (Traditional Medicines: Global Situation, Issues and Challenges). Geneva","author":"Robinon M. R.","year":"2011"},{"key":"e_1_2_8_11_2","volume-title":"Medicinal Plants of Bangladesh","author":"Ghani A.","year":"2003"},{"key":"e_1_2_8_12_2","volume-title":"Chromatography: Practical Pharmaceutical Chemistry","author":"Beckett A. H.","year":"1986"},{"key":"e_1_2_8_13_2","volume-title":"A Text Book of Pharmacognosy","author":"Trease G. E.","year":"1989"},{"key":"e_1_2_8_14_2","first-page":"412","article-title":"Acetic acid-induced analgesic screening","volume":"18","author":"Koster R.","year":"1959","journal-title":"Federation Proceedings"},{"key":"e_1_2_8_15_2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0022-3565(25)03823-6","article-title":"A method for determining loss of pain sensation","volume":"72","author":"D\u2032amour F. E.","year":"1941","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2005.03.002"},{"key":"e_1_2_8_17_2","volume-title":"Screening Methods in Pharmacology","author":"Turner R. A.","year":"1965"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1983.tb10504.x"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1968.tb00973.x"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2012.01.018"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(80)90377-5"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(88)90014-7"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6087456"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00790-6"},{"key":"e_1_2_8_25_2","first-page":"103","article-title":"Gangliosides antinociceptive effects in rodents","volume":"272","author":"Amico-Roxas M.","year":"1984","journal-title":"Archives Internationales de Pharmacodynamie et de Therapie"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.02.040184.002003"},{"key":"e_1_2_8_27_2","volume-title":"Drug Discovery and Evaluation: Pharmacological Assays","author":"Vogel H.","year":"2007"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-28753-4_4375"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(85)90145-9"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1998.tb01478.x"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/976764"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.06.014"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-009-0085-8"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb08316.x"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199406303302609"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-8055-3_6"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9343(01)00834-8"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0658-8"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.12980\/apjtb.4.2014c1020"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1296.157743"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1573(199703)11:2<118::AID-PTR38>3.0.CO;2-J"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.40.2452"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/0262-1746(85)90157-X"},{"key":"e_1_2_8_44_2","first-page":"555","article-title":"Bioactivity of flavonoids","volume":"48","author":"Robak J.","year":"1996","journal-title":"Polish Journal of Pharmacology"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1515\/znc-1994-3-412"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2016\/3820704.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2016\/3820704.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2016\/3820704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T06:01:16Z","timestamp":1748757676000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2016\/3820704"}},"subtitle":[],"editor":[{"given":"Olumayokun A.","family":"Olajide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1155\/2016\/3820704"],"URL":"https:\/\/doi.org\/10.1155\/2016\/3820704","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2015-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3820704"}}