{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:04:12Z","timestamp":1789621452351,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T00:00:00Z","timestamp":1482969600000},"content-version":"vor","delay-in-days":363,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30973720"],"award-info":[{"award-number":["30973720"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31500685"],"award-info":[{"award-number":["31500685"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571803"],"award-info":[{"award-number":["31571803"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31071497"],"award-info":[{"award-number":["31071497"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31271859"],"award-info":[{"award-number":["31271859"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY16C200001"],"award-info":[{"award-number":["LY16C200001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY16C050002"],"award-info":[{"award-number":["LY16C050002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Reactive oxygen species are products of cellular metabolism and assigned important roles in biomedical science as deleterious factors in pathologies. In fact, some studies have shown that the therapeutic benefits of taking antioxidants were limited and the potential for therapeutic intervention remains unclear. New evidences showed that ROS have some ability of intercellular transportation. For treating allergic rhinitis, as a novel intracellular superoxide quencher, TAT\u2010SOD applied to acupoints LI 20 instead of directly to nasal cavity can be used to test that. TTA group apply TAT\u2010SOD cream prepared by adding purified TAT\u2010SOD to the vehicle cream to acupoints LI 20, while placebo group used the vehicle cream instead. TTN group applied the same TAT\u2010SOD cream directly to nasal cavity three times daily. Symptom scores were recorded at baseline and days 8 and 15. For the overall efficacy rate, TTA group was 81.0%, while placebo group was 5.9% and TTN was 0%. Malondialdehyde levels decreased observably in TTA group, and superoxide dismutase, catalase, and glutathione peroxidase levels remained basically unaffected. Enzymatic scavenging of the intracellular superoxide at acupoints LI 20 proved to be effective in treating allergic rhinitis, while no improvement was observed with the placebo group and TTN group.<\/jats:p>","DOI":"10.1155\/2016\/3830273","type":"journal-article","created":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T21:04:16Z","timestamp":1483045456000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Topical Application of TAT\u2010Superoxide Dismutase in Acupoints LI 20 on Allergic Rhinitis"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0934-5198","authenticated-orcid":false,"given":"Jing-Ke","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4771-5316","authenticated-orcid":false,"given":"Ming-Ming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Feng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4882-9662","authenticated-orcid":false,"given":"Shu-Tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Wu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jing","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8011-9260","authenticated-orcid":false,"given":"Tian-Bao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3184-7290","authenticated-orcid":false,"given":"Ping-Fan","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,29]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1979.59.3.527"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/981675"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9084(96)88119-3"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.03.010"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(99)00242-7"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00018.2001"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/10715760310001594631"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.05.055"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.111.186130"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2014.05.026"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001194"},{"key":"e_1_2_8_12_2","first-page":"4559","article-title":"Modulation of intercellular ROS signaling of human tumor cells","volume":"29","author":"Bechtel W.","year":"2009","journal-title":"Anticancer Research"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-013-1067-4"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bihy.2009.07.005"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.09.036"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/286989"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2014.6.2.105"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.126780"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.05.018"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03413.x"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00910.2004"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(01)00734-1"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.04.036"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/608026"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00540.x"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.01.037"},{"key":"e_1_2_8_27_2","volume-title":"WHO Standard Acupuncture Point Locations in the Western Pacific Region","author":"World Health Organization Regional Office for the Western Pacific","year":"2008"},{"key":"e_1_2_8_28_2","first-page":"166","article-title":"Chinese Medicine Department of Otolaryngology Head and Neck Surgery Branch: principles of diagnosis and treatment of allergic rhinitis and recommended solutions","volume":"40","author":"Chinese Otorhinolaryngology Head and Neck Surgery Editorial Board","year":"2005","journal-title":"Chinese Journal of Otorhinolaryngology Head and Neck Surgery"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.2001.0878"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1142\/s0192415x7500027x"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.09.013"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0091-6749(98)70053-3"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0891-5849(00)00232-x"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(90)90206-Q"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.04.060"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2013.08.012"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.01.082"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.10185"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-8-75"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-1-200507050-00005"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2016\/3830273.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2016\/3830273.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2016\/3830273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T01:05:12Z","timestamp":1722906312000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2016\/3830273"}},"subtitle":[],"editor":[{"given":"Jae Youl","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1155\/2016\/3830273"],"URL":"https:\/\/doi.org\/10.1155\/2016\/3830273","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2016-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3830273"}}