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The pain threshold was measured using the potassium iontophoresis method. The levels of c\u2010Fos were determined with Streptavidin\u2010Biotin Complex immunohistochemistry. The results showed pain threshold induced by EA at set of Baihui\u2010Santai acupoints was 44.74<jats:italic>%<\/jats:italic> \u00b1 4.56<jats:italic>%<\/jats:italic> higher than that by EA at set of Housanli acupoints (32.64<jats:italic>%<\/jats:italic> \u00b1 5.04<jats:italic>%<\/jats:italic>). Compared with blank control, EA at two sets of acupoints increased c\u2010Fos expression in the medial septal nucleus (MSN), the arcuate nucleus (ARC), the nucleus amygdala basalis (AB), the lateral habenula nucleus (HL), the ventrolateral periaqueductal grey (vlPAG), the locus coeruleus (LC), the nucleus raphe magnus (NRM), the pituitary gland, and spinal cord dorsal horn (SDH). Compared with EA at set of Housanli points, EA at set of Baihui\u2010Santai points induced increased c\u2010Fos expression in AB but decrease in MSN, the paraventricular nucleus of the hypothalamus, HL, and SDH. It suggests that ARC\u2010PAG\u2010NRM\/LC\u2010SDH and the hypothalamus\u2010pituitary may be the common activated neural pathways taking part in EA\u2010induced analgesia at the two sets of acupoints.<\/jats:p>","DOI":"10.1155\/2016\/3840202","type":"journal-article","created":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T18:05:30Z","timestamp":1467137130000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Analgesic Neural Circuits Are Activated by Electroacupuncture at Two Sets of Acupoints"],"prefix":"10.1155","volume":"2016","author":[{"given":"Man-Li","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Ying","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8304-0398","authenticated-orcid":false,"given":"Kuang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2065-279X","authenticated-orcid":false,"given":"Ming-Xing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,27]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2008.10.047"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nel053"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.12.064"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1142\/s0192415x03001478"},{"key":"e_1_2_9_5_2","first-page":"401","article-title":"Veterinary acupuncture","volume":"40","author":"Haltrecht H.","year":"1999","journal-title":"The Canadian Veterinary Journal"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1142\/s0192415x12500176"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/943198"},{"key":"e_1_2_9_8_2","first-page":"475","article-title":"Frequency as the cardinal determinant for electroacupuncture analgesia to be reversed by opioid antagonists","volume":"38","author":"Han J.","year":"1986","journal-title":"Sheng Li Xue Bao"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91088-x"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2014.08.004"},{"key":"e_1_2_9_11_2","first-page":"1166","article-title":"Effect of intracerebral microinjection of naloxone on acupuncture- and morphine-analgesia in the rabbit","volume":"24","author":"Zhou Z. 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