{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:16:23Z","timestamp":1772763383425,"version":"3.50.1"},"reference-count":10,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2016]]},"abstract":"Aims<\/jats:italic>. MicroRNAs (miRNAs) are involved in the pathogenesis of coronary artery disease (CAD). The objective of this study is to determine plasma levels of miR-10a in CAD and analyze its association with the severity of CAD.Materials and Methods<\/jats:italic>. Plasma miR-10a levels in 60 CAD patients including stable angina pectoris (SAP) (n<\/mml:mi>=<\/mml:mo>29<\/mml:mn><\/mml:math>), unstable angina pectoris (UAP) or non-ST elevation myocardial infarction (MI) (NSTEMI) (n<\/mml:mi>=<\/mml:mo>17<\/mml:mn><\/mml:math>), or ST elevation MI (STEMI) (n<\/mml:mi>=<\/mml:mo>14<\/mml:mn><\/mml:math>) and 20 non-CAD subjects were assessed by real-time polymerase chain reaction (qRT-PCR), and associations of miR-10a levels with risk factors of CAD and its severity were analyzed.Results<\/jats:italic>. The qRT-PCR results showed that plasma miR-10a levels were decreased in CAD patients, and CAD with high SYNTAX scores or STEMI was significantly associated with lower miR-10a levels.Conclusions<\/jats:italic>. Lower plasma miR-10a levels were negatively associated with the presence as well as severity of CAD, and plasma miR-10a can act as a potential biomarker for estimating the presence and severity of CAD.<\/jats:p>","DOI":"10.1155\/2016\/3841927","type":"journal-article","created":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T11:36:18Z","timestamp":1464003378000},"page":"1-5","source":"Crossref","is-referenced-by-count":17,"title":["Plasma miR-10a: A Potential Biomarker for Coronary Artery Disease"],"prefix":"10.1155","volume":"2016","author":[{"given":"Liyun","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bairong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songbiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoliang","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiufang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000152"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa0908610"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.162487"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2015.02.003"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2012.04.013"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/730535"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002120107"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1039\/c5an01762a"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.05.008"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.10.008"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2016\/3841927.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2016\/3841927.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2016\/3841927.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T10:03:16Z","timestamp":1469527396000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/dm\/2016\/3841927\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":10,"alternative-id":["3841927","3841927"],"URL":"https:\/\/doi.org\/10.1155\/2016\/3841927","relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"value":"0278-0240","type":"print"},{"value":"1875-8630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}