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Standard antibiotic therapy has a failure rate of more than 25% from antibiotic resistance. The primary aim of this observational pilot study was to test the feasibility of a large\u2010scale clinical trial of Conifer Green Needle Complex (CGNC) to treat precancerous gastric lesions. Secondary aims were to investigate <jats:italic>H. pylori<\/jats:italic> infection, stomach function, and histopathology of the gastric mucosa. <jats:italic>Methods<\/jats:italic>. A tablet form of CGNC (extracted from <jats:italic>Pinus sylvestris<\/jats:italic> and <jats:italic>Picea abies<\/jats:italic> (L) Karst) was prescribed to 26 patients with precancerous gastric lesions (two tablets, 100\u2009mg CGNC\/tablet, three times per day for six months). Another 24 patients received no treatment. <jats:italic>Results.<\/jats:italic> Compared with control patients, CGNC\u2010treated patients showed total or partial regression (using the quantitative Rome III diagnostic criteria) of dyspeptic symptoms (92.3%, <jats:italic>p<\/jats:italic> &lt; 0.0001), eradication of <jats:italic>H. pylori<\/jats:italic> infection (57.1%, <jats:italic>p<\/jats:italic> &lt; 0.03), a reduction in endoscopic signs of gastritis (92.3%, <jats:italic>p<\/jats:italic> &lt; 0.001), an increase of pepsinogen\u2010pepsin in the gastric juice (57.7%, <jats:italic>p<\/jats:italic> &lt; 0.05), and total regression or reduction in the degree of intestinal metaplasia (46.2%, <jats:italic>p<\/jats:italic> &lt; 0.05) and lymphoplasmacytic infiltration (53.8%, <jats:italic>p<\/jats:italic> &lt; 0.05). <jats:italic>Conclusions.<\/jats:italic> This study justifies a randomised\u2010controlled trial with CGNC in patients with atrophic gastritis.<\/jats:p>","DOI":"10.1155\/2016\/3848409","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T21:20:03Z","timestamp":1480368003000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Conifer Green Needle Complex in Patients with Precancerous Gastric Lesions: An Observational Pilot Study"],"prefix":"10.1155","volume":"2016","author":[{"given":"Vladimir","family":"Bespalov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Sherbakov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor","family":"Novik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentin","family":"Kalinovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamran","family":"Shamsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5612-0402","authenticated-orcid":false,"given":"Vagif","family":"Soultanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,28]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-492-0_23"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.06.026"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2013.01.006"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700719"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2010.07.014"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/145749690609500402"},{"key":"e_1_2_8_7_2","first-page":"302","article-title":"Risk factors in gastric cancer","volume":"14","author":"Compare D.","year":"2010","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-011-0226-4"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.853"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695x.2011.00865.x"},{"key":"e_1_2_8_11_2","first-page":"114","volume-title":"Study and Application of Therapeutic-Prophylactic Medications Based on Natural Biologically Active Compounds","author":"Roschin V. 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