{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T09:47:25Z","timestamp":1775296045816,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Russian Scientific and Technological Complex","award":["RFMEF157514X0037"],"award-info":[{"award-number":["RFMEF157514X0037"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>A series of novel quaternary ammonium 4-deoxypyridoxine derivatives was synthesized. Two compounds demonstrated excellent activity against a panel of Gram-positive methicillin-resistant<jats:italic>S. aureus<\/jats:italic>strains with MICs in the range of 0.5\u20132\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL, exceeding the activity of miramistin. At the same time, both compounds were inactive against the Gram-negative<jats:italic>E. coli<\/jats:italic>and<jats:italic>P. aeruginosa<\/jats:italic>strains. Cytotoxicity studies on human skin fibroblasts and embryonic kidney cells demonstrated that the active compounds possessed similar toxicity with benzalkonium chloride but were slightly more toxic than miramistin. SOS-chromotest in<jats:italic>S. typhimurium<\/jats:italic>showed the lack of DNA-damage activity of both compounds; meanwhile, one compound showed some mutagenic potential in the Ames test. The obtained results make the described chemotype a promising starting point for the development of new antibacterial therapies.<\/jats:p>","DOI":"10.1155\/2016\/3864193","type":"journal-article","created":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T17:18:47Z","timestamp":1475687927000},"page":"1-8","source":"Crossref","is-referenced-by-count":28,"title":["Synthesis and Antibacterial Activity of Quaternary Ammonium 4-Deoxypyridoxine Derivatives"],"prefix":"10.1155","volume":"2016","author":[{"given":"Nikita V.","family":"Shtyrlin","sequence":"first","affiliation":[{"name":"Kazan (Volga Region) Federal University, Kremlyovskaya St. 18, Kazan 420008, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey V.","family":"Sapozhnikov","sequence":"additional","affiliation":[{"name":"Kazan (Volga Region) Federal University, Kremlyovskaya St. 18, Kazan 420008, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albina S.","family":"Galiullina","sequence":"additional","affiliation":[{"name":"Kazan (Volga Region) Federal University, Kremlyovskaya St. 18, Kazan 420008, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Airat R.","family":"Kayumov","sequence":"additional","affiliation":[{"name":"Kazan (Volga Region) Federal University, Kremlyovskaya St. 18, Kazan 420008, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana V.","family":"Bondar","sequence":"additional","affiliation":[{"name":"Kazan (Volga Region) Federal University, Kremlyovskaya St. 18, Kazan 420008, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena P.","family":"Mirchink","sequence":"additional","affiliation":[{"name":"Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, B. 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