{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:45:09Z","timestamp":1776944709469,"version":"3.51.4"},"reference-count":33,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Analyses emphasizing gender-related differences in acute and long-term outcomes following MitraClip therapy for significant mitral regurgitation (MR) are rare.<jats:italic>Methods<\/jats:italic>. 592 consecutive patients (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn fontstyle=\"italic\">75<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">8.7<\/mml:mn><\/mml:math>years, 362 men, 230 women) underwent clinical and echocardiographic follow-up for a median of 2.13 (0.99\u20134.02) years.<jats:italic>Results.<\/jats:italic>Significantly higher prevalence of cardiovascular comorbidities, renal failure, and adverse echocardiographic parameters in men resulted in longer device time<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.007<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>and higher numbers of implanted clips<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0075<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>, with equal procedural success<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">1.0<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>. Rehospitalization for heart failure did not differ<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>p<\/mml:mi><mml:mo stretchy=\"false\">[<\/mml:mo><mml:mi mathvariant=\"normal\">l<\/mml:mi><mml:mi mathvariant=\"normal\">o<\/mml:mi><mml:mi mathvariant=\"normal\">g<\/mml:mi><mml:mi mathvariant=\"normal\">r<\/mml:mi><mml:mi mathvariant=\"normal\">a<\/mml:mi><mml:mi mathvariant=\"normal\">n<\/mml:mi><mml:mi mathvariant=\"normal\">k<\/mml:mi><mml:mo stretchy=\"false\">]<\/mml:mo><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.288<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>while survival was higher in women<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>p<\/mml:mi><mml:mo stretchy=\"false\">[<\/mml:mo><mml:mi mathvariant=\"normal\">l<\/mml:mi><mml:mi mathvariant=\"normal\">o<\/mml:mi><mml:mi mathvariant=\"normal\">g<\/mml:mi><mml:mi mathvariant=\"normal\">r<\/mml:mi><mml:mi mathvariant=\"normal\">a<\/mml:mi><mml:mi mathvariant=\"normal\">n<\/mml:mi><mml:mi mathvariant=\"normal\">k<\/mml:mi><mml:mo stretchy=\"false\">]<\/mml:mo><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0317<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>. Logarithmic increase of NT-proBNP was a common independent predictor of death. Hypercholesterolemia and peripheral artery disease were predictors of death only in men while ischemic and dilative cardiomyopathy (CM) and age were predictors in women. Independent predictors of rehospitalization for heart failure were severely reduced ejection fraction and success in men while both ischemic and dilative CM, logistic EuroSCORE, and MR severity were predictive in women.<jats:italic>Conclusions<\/jats:italic>. Higher numbers of implanted clips and longer device time are likely related to more comorbidities in men. Procedural success and acute and mid-term clinical outcomes were equal. Superior survival for women in long-term analysis is presumably attributable to a comparatively better preprocedural health.<\/jats:p>","DOI":"10.1155\/2016\/3934842","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T21:02:39Z","timestamp":1456952559000},"page":"1-11","source":"Crossref","is-referenced-by-count":19,"title":["Transcatheter Mitral Valve Repair in Surgical High-Risk Patients: Gender-Specific Acute and Long-Term Outcomes"],"prefix":"10.1155","volume":"2016","author":[{"given":"Eike","family":"Tigges","sequence":"first","affiliation":[{"name":"Department of General and Interventional Cardiology, University Heart Center, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Kalbacher","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology, University Heart Center, University 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