{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:34:01Z","timestamp":1726446841077},"reference-count":42,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"IRCCS Policlinico San Donato Ricerca Corrente Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Context<\/jats:italic>. Hypovitaminosis D frequently occurs in early life and increases with age. Vitamin D has been suggested to influence cardiac performance and N-terminal-pro-type B natriuretic peptide (NT-proBNP) release in adults with heart failure.<jats:italic>Objectives<\/jats:italic>. To assess the vitamin D status and the impact of hypovitaminosis D on circulating NT-proBNP levels in young patients with congenital heart defects (CHD).<jats:italic>Design and Patients<\/jats:italic>. This cross-sectional study included the assessment of serum 25-hydroxyvitamin D (25OHD), parathyroid function markers, and NT-proBNP levels in a series of 230 young in-patients (117 females, 113 males; 6.4 (4.0\u20139.1) years (median, interquartile range)) with CHD.<jats:italic>Results<\/jats:italic>. Serum 25OHD levels &lt;20\u2009ng\/mL were detected in 55.3% of patients. Optimal 25OHD levels (&gt;30\u2009ng\/mL) occurred in 25% of patients. Serum 25OHD levels inversely correlated with age (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>-<\/mml:mo><mml:mn fontstyle=\"italic\">0.169<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.013<\/mml:mn><\/mml:math>) and height standard deviation score (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>-<\/mml:mo><mml:mn fontstyle=\"italic\">0.269<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>). After correction for age, 25OHD negatively correlated with serum PTH levels (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>\u03b2<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>-<\/mml:mo><mml:mn fontstyle=\"italic\">0.200<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.002<\/mml:mn><\/mml:math>). PTH levels above the upper quartile (44\u2009pg\/mL) occurred in 32% of hypovitaminosis D patients. Serum NT-proBNP levels were not correlated with 25OHD and PTH levels.<jats:italic>Conclusions<\/jats:italic>. Half of the young CHD patients were diagnosed with 25OHD deficiency and a third of hypovitaminosis D patients experienced hyperparathyroidism. Nonetheless, serum NT-proBNP levels were not associated with hypovitaminosis D as well as hyperparathyroidism.<\/jats:p>","DOI":"10.1155\/2016\/3970284","type":"journal-article","created":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T16:01:34Z","timestamp":1454515294000},"page":"1-7","source":"Crossref","is-referenced-by-count":4,"title":["Serum NT-proBNP Levels Are Not Related to Vitamin D Status in Young Patients with Congenital Heart Defects"],"prefix":"10.1155","volume":"2016","author":[{"given":"E.","family":"Passeri","sequence":"first","affiliation":[{"name":"Endocrinology Unit, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Rigolini","sequence":"additional","affiliation":[{"name":"Laboratorio di Chimica Clinica, IRCCS Policlinico San Donato, 20097 San Donato Milanese, 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