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Reliable biomarker for the prediction of deterioration in EV71-infected children with central nervous system (CNS) involvement may reduce the cardiopulmonary failure and mortality. Here, we found that serum IL-27 levels were significantly higher in stage III EV71-infected HFMD patients with early cardiopulmonary failure and strong correlation with CRP levels.<jats:italic>IL27p28<\/jats:italic>polymorphisms (rs153109, rs17855750, and rs181206) did not influence IL-27 production, and these three SNPs were not associated with EV71 infection risk and clinical stage. IL-27 can be used as an prediction indicator for early cardiopulmonary failure in EV71-infected children with CNS involvement.<\/jats:p>","DOI":"10.1155\/2016\/4025167","type":"journal-article","created":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T17:02:51Z","timestamp":1466010171000},"page":"1-8","source":"Crossref","is-referenced-by-count":6,"title":["Interleukin-27 as a Novel Biomarker for Early Cardiopulmonary Failure in Enterovirus 71-Infected Children with Central Nervous System Involvement"],"prefix":"10.1155","volume":"2016","author":[{"given":"Mingyuan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Sanitary Analysis, Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China"},{"name":"Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan 523808, 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