{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:09:53Z","timestamp":1793398193490,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic>Delayed union and nonunion are common complications in atypical femoral fractures (AFFs) despite having good fracture fixation. Demineralized bone matrix (DBM) is a successfully proven method for enhancing fracture healing of the long bone fracture and nonunion and should be used in AFFs. This study aimed to compare the outcome after subtrochanteric AFFs (ST-AFFs) fixation with and without DBM.<jats:italic>Materials and Methods<\/jats:italic>. A prospective study was conducted on 9 ST-AFFs patients using DBM (DBM group) during 2013-2014 and compared with a retrospective consecutive case series of ST-AFFs patients treated without DBM (2010\u20132012) (NDBM group, 9 patients). All patients were treated with the same standard guideline and followed up until fractures completely united. Postoperative outcomes were then compared.<jats:italic>Results<\/jats:italic>. DBM group showed a significant shorter healing time than NDBM group (28.1 \u00b1 14.4 versus 57.9 \u00b1 36.8 weeks,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.04<\/mml:mn><\/mml:math>). Delayed union was found in 4 patients (44%) in DBM group compared with 7 patients (78%) in NDBM group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>). No statistical difference of nonunion was demonstrated between both groups (DBM = 1 and NDBM = 2,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>). Neither postoperative infection nor severe local tissue reaction was found.<jats:italic>Conclusions<\/jats:italic>. DBM is safe and effective for accelerating the fracture healing in ST-AFFx and possibly reduces nonunion after fracture fixation. Trial registration number is<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.in.th\/index.php?tp=regtrials&amp;menu=trialsearch&amp;smenu=fulltext&amp;task=search&amp;task2=view1&amp;id=1575\">TCTR20151021001<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2016\/4061539","type":"journal-article","created":{"date-parts":[[2016,2,28]],"date-time":"2016-02-28T21:00:57Z","timestamp":1456693257000},"page":"1-8","source":"Crossref","is-referenced-by-count":16,"title":["Demineralized Bone Matrix Add-On for Acceleration of Bone Healing in Atypical Subtrochanteric Femoral Fracture: A Consecutive Case-Control Study"],"prefix":"10.1155","volume":"2016","author":[{"given":"Noratep","family":"Kulachote","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1936-4456","authenticated-orcid":true,"given":"Paphon","family":"Sa-ngasoongsong","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norachart","family":"Sirisreetreerux","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pongsthorn","family":"Chanplakorn","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praman","family":"Fuangfa","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanyut","family":"Suphachatwong","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiwat","family":"Wajanavisit","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.253"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1998"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-013-2259-9"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/ta.0b013e31821957e3"},{"issue":"10","key":"5","doi-asserted-by":"crossref","first-page":"939","DOI":"10.3928\/01477447-20061001-07","volume":"29","year":"2006","journal-title":"Orthopedics"},{"issue":"1","key":"6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s00264-002-0388-7","volume":"27","year":"2003","journal-title":"International Orthopaedics"},{"issue":"7","key":"7","first-page":"329","volume":"34","year":"2005","journal-title":"The American Journal of 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