{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T08:10:52Z","timestamp":1693642252937},"reference-count":11,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Pulmonary alveolar proteinosis (PAP) is a rare condition characterized by dysfunctional alveolar macrophages, which ineffectively clear surfactant and typically cause mild hypoxemia. Characteristic Computed Tomography findings are septal reticulations superimposed on ground-glass opacities in a crazy paving pattern, with a clear juxtaposition between affected and unaffected parenchyma. While traditionally PAP was diagnosed via biopsy, bronchoalveolar lavage (BAL) is usually sufficient; the fluid appears milky, and on microscopic examination there are foamy macrophages with eosinophilic granules and extracellular hyaline material that is Periodic Acid-Schiff positive. Standard therapy is whole lung lavage (WLL), although novel treatments are under development. The case presented is a 55-year-old woman with six months of progressive dyspnea, who developed hypoxemic respiratory failure requiring mechanical ventilation; she had typical findings of PAP on imaging and BAL. WLL was ultimately successful in restoring adequate oxygenation. Respiratory failure of this magnitude is a rare finding in PAP.<\/jats:p>","DOI":"10.1155\/2016\/4064539","type":"journal-article","created":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T17:01:14Z","timestamp":1463418074000},"page":"1-4","source":"Crossref","is-referenced-by-count":2,"title":["Rare Presentation of Pulmonary Alveolar Proteinosis Causing Acute Respiratory Failure"],"prefix":"10.1155","volume":"2016","author":[{"given":"Ryan R.","family":"Kroll","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Queen\u2019s University, Etherington Hall, Room 3033, 94 Stuart Street, Kingston, ON, Canada K7L 3N6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer","family":"Kumar","sequence":"additional","affiliation":[{"name":"Trillium Health Partners-Credit Valley Hospital Site, Mississauga, ON, Canada L5M 2N1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald F.","family":"Grossman","sequence":"additional","affiliation":[{"name":"University of Toronto, Trillium Health Partners-Credit Valley Hospital Site, Mississauga, ON, Canada L5M 2N1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Price","sequence":"additional","affiliation":[{"name":"Trillium Health Partners-Credit Valley Hospital Site, Mississauga, ON, Canada L5M 2N1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Srigley","sequence":"additional","affiliation":[{"name":"Laboratory Medicine and Genetics Program, Trillium Health Partners-Credit Valley Hospital Site, Mississauga, ON, Canada L5M 2N1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.046"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/528948"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00001311"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.3.1024"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050563"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.4081\/cp.2011.e53"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.3.8118651"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-1573"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s13244-010-0060-5"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/841530"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2012.02274.x"}],"container-title":["Canadian Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/2016\/4064539.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/2016\/4064539.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/2016\/4064539.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T15:07:34Z","timestamp":1471532854000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crj\/2016\/4064539\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":11,"alternative-id":["4064539","4064539"],"URL":"https:\/\/doi.org\/10.1155\/2016\/4064539","relation":{},"ISSN":["1198-2241","1916-7245"],"issn-type":[{"value":"1198-2241","type":"print"},{"value":"1916-7245","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}