{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:32:52Z","timestamp":1767706372050,"version":"3.41.2"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,31]],"date-time":"2016-07-31T00:00:00Z","timestamp":1469923200000},"content-version":"vor","delay-in-days":212,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573806","81403389","81302945"],"award-info":[{"award-number":["81573806","81403389","81302945"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To explore the efficacy of Chinese herbal medicine in treating diarrhea\u2010predominant irritable bowel syndrome (D\u2010IBS). <jats:italic>Methods<\/jats:italic>. Four English and four Chinese databases were searched through November, 2015. Randomized, double\u2010blind and placebo\u2010controlled trials were selected. Data extraction and quality evaluation were performed by two authors independently. RevMan 5.2.0 software was applied to analyze the data of included trials. <jats:italic>Results<\/jats:italic>. A total of 14 trials involving 1551 patients were included. Meta\u2010analysis demonstrated superior global symptom improvement (RR = 1.62; 95% CI 1.31, 2.00; <jats:italic>P<\/jats:italic> &lt; 0.00001; number needed to treat = 3.6), abdominal pain improvement (RR = 1.95; 95% CI 1.61, 2.35; <jats:italic>P<\/jats:italic> &lt; 0.00001), diarrhea improvement (RR = 1.87; 95% CI 1.60, 2.20; <jats:italic>P<\/jats:italic> &lt; 0.00001), pain threshold assessment (MD = 54.53; 95% CI 38.76, 70.30; <jats:italic>P<\/jats:italic> &lt; 0.00001), and lower IBS Symptom Severity Score (SMD = \u22121.01; 95% CI \u22121.72, \u22120.30; <jats:italic>P<\/jats:italic> = 0.005), when compared with placebo, while for defecation threshold assessment, quality of life, and adverse events, no differences were found between treatment groups and controlled groups. <jats:italic>Conclusion<\/jats:italic>. This meta\u2010analysis shows that Chinese herbal medicine is an effective and safe treatment for D\u2010IBS. However, due to the small sample size and high heterogeneity, further studies are required.<\/jats:p>","DOI":"10.1155\/2016\/4071260","type":"journal-article","created":{"date-parts":[[2016,7,31]],"date-time":"2016-07-31T21:02:25Z","timestamp":1469998945000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Efficacy of Chinese Herbal Medicine for Diarrhea\u2010Predominant Irritable Bowel Syndrome: A Meta\u2010Analysis of Randomized, Double\u2010Blind, Placebo\u2010Controlled Trials"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0900-3502","authenticated-orcid":false,"given":"Jia-Jie","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Lan","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Song","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6802-0708","authenticated-orcid":false,"given":"Yu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Wei","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-Guo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru-Han","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Qin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8572-921X","authenticated-orcid":false,"given":"Wei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,31]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2010.04.008"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.02.029"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.15386\/cjmed-449"},{"key":"e_1_2_11_5_2","first-page":"26","article-title":"An epidemiologic study of irritable bowel syndrome in Beijing\u2014a stratified randomized study by clustering sampling","volume":"21","author":"Pan G. Z.","year":"2000","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"e_1_2_11_6_2","first-page":"278","article-title":"A population-based epidemiologic study of irritable bowel syndrome in Guangdong province","volume":"84","author":"Xiong L.-S.","year":"2004","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.12.015"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i34.12144"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006442.pub2"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127815"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i20.6031"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2010.01177.x"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i8.2315"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139389"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.577"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1726-4901(09)70375-2"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/605460"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00576.x"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510023134"},{"key":"e_1_2_11_20_2","article-title":"Herbal medicines for treatment of irritable bowel syndrome","volume":"25","author":"Liu J. P.","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.454"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122397"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/232147"},{"key":"e_1_2_11_24_2","series-title":"Version 510","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins J. P. T.","year":"2011"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.18.1585"},{"volume-title":"Treatment of Irritable Bowel Syndrome with Shu Gan Jian Pi Decoction: A Randomized Trial","year":"2002","author":"Luo T. J.","key":"e_1_2_11_28_2"},{"key":"e_1_2_11_29_2","first-page":"218","article-title":"Effect of Chang Ji An oral liquid on stimulated functional area of brain in patients of diarrhea-predominant irritable bowel syndrome of disharmony between liver and spleen","volume":"13","author":"Shen J.","year":"2005","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine On Gastro-Spleen"},{"key":"e_1_2_11_30_2","first-page":"967","article-title":"Effect of Chang Ji an oral liquid on activated signal alterative intensity in algesthesia domain in patients with diarrhea type irritable bowel syndrome due to Gan-Pi disharmony","volume":"25","author":"Shen J.","year":"2005","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine"},{"key":"e_1_2_11_31_2","first-page":"84","article-title":"Tongxiening granule in the treatment of diarrhea-predominant irritable bowel syndrome(stagnation of the liver-Qi attacking the spleen): a prospective, randomized, placebo-controlled, double-blind clinical trial","volume":"6","author":"Wang G.","year":"2006","journal-title":"Chinese Journal of Evidence-Based Medicine"},{"volume-title":"The Effects of Soothing Liver and Activating Spleen Method on the Visceral Hypersensitivity of Diarrhea-Predominant Irritable Bowel Syndrome and the Research of this Mechanism","year":"2008","author":"Cheng H. H.","key":"e_1_2_11_32_2"},{"key":"e_1_2_11_33_2","first-page":"33","article-title":"A randomized, double-blinded and placebo-controlled trial of \u2018Chang Ji Tai Granule\u2019 in treating diarrhea-predominant irritable bowel syndrome","volume":"44","author":"Li Y. M.","year":"2010","journal-title":"Shanghai University of Traditional Chinese Medicine"},{"key":"e_1_2_11_34_2","first-page":"327","article-title":"Effects of Tong Xie Ning granule in treatment of diarrhea-predominant irritable bowel syndrome: a randomized, double-blind, placebo-controlled, multicenter study","volume":"30","author":"Chen D. F.","year":"2010","journal-title":"Chinese Journal of Digestion"},{"key":"e_1_2_11_35_2","unstructured":"TangX. D. LiZ. H. LiB. S. GaoR. WangF. Y. andLuF. Treatment of diarrhea-predominant irritable bowel syndrome with Chang An Yi Hao decoction: a randomized double-blinded and placebo-controlled trial Proceedings of the 7th National Symposium of Rehabilitation Medicine Health Professional Committee 2011 Chinese Association of Integrative Medicine 1\u20139."},{"volume-title":"Clinical Observation of Warmming the Kidney and Fortifying the Spleen Therapy in Treating Diarrhea-Predominant Irritable Bowel Syndrome","year":"2011","author":"Li Y. F.","key":"e_1_2_11_36_2"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0254-6272(14)60030-3"},{"key":"e_1_2_11_38_2","first-page":"1097","article-title":"Treatment of diarrhea-predominant irritable bowel syndrome with Shu Gan Jian Pi Wen Shen decoction: a randomized controlled trial","volume":"31","author":"Cai L. J.","year":"2012","journal-title":"Chinese Archives of Traditional Chinese Medicine"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/824605"},{"key":"e_1_2_11_40_2","first-page":"1","article-title":"A randomized, double-blinded, placebo-controlled research on Chang Ji Tai combined with percutaneous accupoint stimulation in the treatment of diarrhea-predominant irritable bowel syndrome","volume":"22","author":"Li Y. M.","year":"2014","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.1142\/s0192415x15500019"},{"key":"e_1_2_11_42_2","first-page":"457","article-title":"Effect of Shen warming Pi strengthening method on the expression of serum T cell subsets in IBS-D rats","volume":"35","author":"Su X. L.","year":"2015","journal-title":"Chinese Journal of Integrative Medicine"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/1757-4749-2-3"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2016\/4071260.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2016\/4071260.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2016\/4071260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:40:25Z","timestamp":1722904825000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2016\/4071260"}},"subtitle":[],"editor":[{"given":"Jiande D. Z.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1155\/2016\/4071260"],"URL":"https:\/\/doi.org\/10.1155\/2016\/4071260","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"type":"print","value":"1741-427X"},{"type":"electronic","value":"1741-4288"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2016-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4071260"}}