{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:48:45Z","timestamp":1792799325808,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T00:00:00Z","timestamp":1458000000000},"content-version":"vor","delay-in-days":74,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Basic Research Program in China","award":["2010CB530400"],"award-info":[{"award-number":["2010CB530400"]}]},{"name":"National Basic Research Program in China","award":["YSN36"],"award-info":[{"award-number":["YSN36"]}]},{"name":"National Basic Research Program in China","award":["81573992"],"award-info":[{"award-number":["81573992"]}]},{"name":"National Basic Research Program in China","award":["81528022"],"award-info":[{"award-number":["81528022"]}]},{"name":"National Basic Research Program in China","award":["81574001"],"award-info":[{"award-number":["81574001"]}]},{"name":"National Basic Research Program in China","award":["81473701"],"award-info":[{"award-number":["81473701"]}]},{"name":"National Basic Research Program in China","award":["81403416"],"award-info":[{"award-number":["81403416"]}]},{"name":"National Basic Research Program in China","award":["PCSIRT, IRT1270"],"award-info":[{"award-number":["PCSIRT, IRT1270"]}]},{"name":"Project in Shanghai University of Traditional Chinese Medicine","award":["2010CB530400"],"award-info":[{"award-number":["2010CB530400"]}],"id":[{"id":"https:\/\/ror.org\/00z27jk27","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Project in Shanghai University of Traditional Chinese Medicine","award":["YSN36"],"award-info":[{"award-number":["YSN36"]}],"id":[{"id":"https:\/\/ror.org\/00z27jk27","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Project in Shanghai University of Traditional Chinese Medicine","award":["81573992"],"award-info":[{"award-number":["81573992"]}],"id":[{"id":"https:\/\/ror.org\/00z27jk27","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Project in Shanghai University of Traditional Chinese Medicine","award":["81528022"],"award-info":[{"award-number":["81528022"]}],"id":[{"id":"https:\/\/ror.org\/00z27jk27","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Project in Shanghai University of Traditional Chinese Medicine","award":["81574001"],"award-info":[{"award-number":["81574001"]}],"id":[{"id":"https:\/\/ror.org\/00z27jk27","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Project in Shanghai University of Traditional Chinese Medicine","award":["81473701"],"award-info":[{"award-number":["81473701"]}],"id":[{"id":"https:\/\/ror.org\/00z27jk27","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Project in Shanghai University of Traditional Chinese Medicine","award":["81403416"],"award-info":[{"award-number":["81403416"]}],"id":[{"id":"https:\/\/ror.org\/00z27jk27","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Project in Shanghai University of Traditional Chinese Medicine","award":["PCSIRT, IRT1270"],"award-info":[{"award-number":["PCSIRT, IRT1270"]}],"id":[{"id":"https:\/\/ror.org\/00z27jk27","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2010CB530400"],"award-info":[{"award-number":["2010CB530400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["YSN36"],"award-info":[{"award-number":["YSN36"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573992"],"award-info":[{"award-number":["81573992"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81528022"],"award-info":[{"award-number":["81528022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81574001"],"award-info":[{"award-number":["81574001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473701"],"award-info":[{"award-number":["81473701"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81403416"],"award-info":[{"award-number":["81403416"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["PCSIRT, IRT1270"],"award-info":[{"award-number":["PCSIRT, IRT1270"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2010CB530400"],"award-info":[{"award-number":["2010CB530400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["YSN36"],"award-info":[{"award-number":["YSN36"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573992"],"award-info":[{"award-number":["81573992"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81528022"],"award-info":[{"award-number":["81528022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81574001"],"award-info":[{"award-number":["81574001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473701"],"award-info":[{"award-number":["81473701"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81403416"],"award-info":[{"award-number":["81403416"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["PCSIRT, IRT1270"],"award-info":[{"award-number":["PCSIRT, IRT1270"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2010CB530400"],"award-info":[{"award-number":["2010CB530400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["YSN36"],"award-info":[{"award-number":["YSN36"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573992"],"award-info":[{"award-number":["81573992"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81528022"],"award-info":[{"award-number":["81528022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81574001"],"award-info":[{"award-number":["81574001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473701"],"award-info":[{"award-number":["81473701"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81403416"],"award-info":[{"award-number":["81403416"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["PCSIRT, IRT1270"],"award-info":[{"award-number":["PCSIRT, IRT1270"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2010CB530400"],"award-info":[{"award-number":["2010CB530400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["YSN36"],"award-info":[{"award-number":["YSN36"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573992"],"award-info":[{"award-number":["81573992"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81528022"],"award-info":[{"award-number":["81528022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81574001"],"award-info":[{"award-number":["81574001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473701"],"award-info":[{"award-number":["81473701"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81403416"],"award-info":[{"award-number":["81403416"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["PCSIRT, IRT1270"],"award-info":[{"award-number":["PCSIRT, IRT1270"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2010CB530400"],"award-info":[{"award-number":["2010CB530400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["YSN36"],"award-info":[{"award-number":["YSN36"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573992"],"award-info":[{"award-number":["81573992"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81528022"],"award-info":[{"award-number":["81528022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81574001"],"award-info":[{"award-number":["81574001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473701"],"award-info":[{"award-number":["81473701"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81403416"],"award-info":[{"award-number":["81403416"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["PCSIRT, IRT1270"],"award-info":[{"award-number":["PCSIRT, IRT1270"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Program for Changjiang Scholars and Innovative Research Team in University","award":["2010CB530400"],"award-info":[{"award-number":["2010CB530400"]}]},{"name":"Program for Changjiang Scholars and Innovative Research Team in University","award":["YSN36"],"award-info":[{"award-number":["YSN36"]}]},{"name":"Program for Changjiang Scholars and Innovative Research Team in University","award":["81573992"],"award-info":[{"award-number":["81573992"]}]},{"name":"Program for Changjiang Scholars and Innovative Research Team in University","award":["81528022"],"award-info":[{"award-number":["81528022"]}]},{"name":"Program for Changjiang Scholars and Innovative Research Team in University","award":["81574001"],"award-info":[{"award-number":["81574001"]}]},{"name":"Program for Changjiang Scholars and Innovative Research Team in University","award":["81473701"],"award-info":[{"award-number":["81473701"]}]},{"name":"Program for Changjiang Scholars and Innovative Research Team in University","award":["81403416"],"award-info":[{"award-number":["81403416"]}]},{"name":"Program for Changjiang Scholars and Innovative Research Team in University","award":["PCSIRT, IRT1270"],"award-info":[{"award-number":["PCSIRT, IRT1270"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells International"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>\n                    We studied the bone mesenchymal stem cells (bMSCs) and gene profiles regulated by\n                    <jats:italic>Er-Xian Decoction<\/jats:italic>\n                    (EXD), a traditional Chinese herbal formula widely used for postmenopausal osteoporosis treatment. Six\u2010month\u2010old female Imprinting Control Region mice that underwent ovariectomy were treated with EXD. After 3 months, bone mass was evaluated by\n                    <jats:italic>\u03bc<\/jats:italic>\n                    CT and histological and immunohistochemical detection. The self\u2010renewal and differentiation capacities of bMSCs were evaluated by colony\u2010forming unit\u2010fibroblastic, colony\u2010forming unit\u2010adipocyte, and alkaline phosphatase staining. In addition, the expression of 26991 genes of bMSCs\n                    <jats:italic>ex vivo<\/jats:italic>\n                    at 2 weeks after EXD\u2010treatment or of bMSCs\n                    <jats:italic>in vitro<\/jats:italic>\n                    after exposure to conditioned serum from EXD\u2010treated rats was measured and analyzed using NimbleGen Gene Expression Profiling and Cluster and pathway analysis. EXD treatment increased bone mass, elevating osteocalcin protein levels\n                    <jats:italic>in vivo<\/jats:italic>\n                    and facilitating the self\u2010renewal and osteoblastic differentiation of bMSCs\n                    <jats:italic>ex vivo<\/jats:italic>\n                    . EXD rescued several gene expressions that were dysregulated by OVX. These genes overlapped and their functions were involved in ten pathways between\n                    <jats:italic>ex vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    experiments. EXD exerts an osteogenic effect on bMSCs in OVX induced osteoporotic mice. Our results contribute to further study of its molecular mechanism and traditional use in the treatment of postmenopausal osteoporosis.\n                  <\/jats:p>","DOI":"10.1155\/2016\/4079210","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T17:01:39Z","timestamp":1458061299000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Er\u2010Xian Decoction Stimulates Osteoblastic Differentiation of Bone Mesenchymal Stem Cells in Ovariectomized Mice and Its Gene Profile Analysis"],"prefix":"10.1155","volume":"2016","author":[{"given":"Shufen","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4190-0913","authenticated-orcid":false,"given":"Qin","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,15]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1142\/s0192415x08005746"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e31827cd3dd"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.04.020"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.04.009"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/241416"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X1450027X"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/490843"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules15074695"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(19991201)75:3&lt;414::AID-JCB7>3.0.CO;2-C"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181dbc101"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1691\/ph.2011.0219"},{"key":"e_1_2_8_12_2","first-page":"751","article-title":"Biochemical markers of bone remodeling: recent data of their applications in managing postmenopausal osteoporosis","volume":"84","author":"Bahlous A.","year":"2006","journal-title":"Tunisie Medicale"},{"key":"e_1_2_8_13_2","first-page":"1673","article-title":"Osteocalcin and bone","volume":"17","author":"Wada S.","year":"2007","journal-title":"Clinical Calcium"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20974"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080325"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-009-9094-9"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/13645700801969758"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms12117635"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3182272ef1"},{"key":"e_1_2_8_20_2","first-page":"672","article-title":"Effect of er-xian decoction and its disassembled prescription on enzyme activities and their gene expression of antioxidant enzymes in aging rat","volume":"15","author":"Shen X. H.","year":"1995","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"e_1_2_8_21_2","first-page":"122","article-title":"Effect of er xian decoction and its subdivisions on granulosa cells secretory function in rats","volume":"26","author":"Dong B.-F.","year":"2006","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2009.10.017"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m606706200"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200610046"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m110.187351"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2008.0206"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009093"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.3109\/09553000903422555"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0089"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-011-9228-8"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/bf02742962"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.022160"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0303"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2008.01.027"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10168"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1159\/000323986"}],"container-title":["Stem Cells International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2016\/4079210.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2016\/4079210.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2016\/4079210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T22:26:01Z","timestamp":1722896761000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2016\/4079210"}},"subtitle":[],"editor":[{"given":"Silvia","family":"Brunelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1155\/2016\/4079210"],"URL":"https:\/\/doi.org\/10.1155\/2016\/4079210","archive":["Portico"],"relation":{},"ISSN":["1687-966X","1687-9678"],"issn-type":[{"value":"1687-966X","type":"print"},{"value":"1687-9678","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2015-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4079210"}}