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Arg. (EOCA) were investigated in normotensive rats. In saline\u2010pretreated anesthetized or conscious rats, intravenous (i.v.) injection of the EOCA induced dose\u2010dependent hypotension. Dose\u2010dependent tachycardia was observed only in conscious rats. In anesthetized rats, cervical bivagotomy failed to enhance EOCA\u2010induced hypotension but unmasked significant bradycardia. In conscious rats, i.v. pretreatment with methylatropine, but not with atenolol or L\u2010NAME, reduced both hypotensive and tachycardiac responses to EOCA. However, hexamethonium pretreatment reverted the EOCA\u2010induced tachycardia into significant bradycardia without affecting the hypotension. In aortic ring preparations precontracted with phenylephrine, EOCA induced a concentration\u2010dependent relaxation that was significantly reduced by vascular endothelium removal and pretreatment with atropine, indomethacin, or glibenclamide but remained unaffected by pretreatment with L\u2010NAME or TEA. It is concluded that i.v. treatment with EOAC decreased blood pressure probably through an active vascular relaxation rather than withdrawal of sympathetic tone. Muscarinic receptor stimulation, liberation of the endothelium\u2010derived prostacyclin, and opening KATP channels are partially involved in the aortic relaxation induced by EOCA and in turn in the mediation of EOCA\u2010induced hypotension. EOCA\u2010induced tachycardia in conscious rats appears to be mediated reflexly through inhibition of vagal drive to the heart.<\/jats:p>","DOI":"10.1155\/2016\/4106502","type":"journal-article","created":{"date-parts":[[2016,11,13]],"date-time":"2016-11-13T21:01:49Z","timestamp":1479070909000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cardiovascular Effects of the Essential Oil of<i>Croton argyrophylloides<\/i>in Normotensive Rats: Role of the Autonomic Nervous System"],"prefix":"10.1155","volume":"2016","author":[{"given":"Thayane Rebeca","family":"Alves-Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Jos\u00e9 Bezerra","family":"de Siqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria Pinto","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9070-5009","authenticated-orcid":false,"given":"Saad","family":"Lahlou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,13]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-695X2008000300023"},{"key":"e_1_2_8_2_2","first-page":"83","article-title":"Antimicrobial substances of superior plants. 44. 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