{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:05:58Z","timestamp":1740157558256,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Osteoporosis"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Aims<\/jats:italic>. To investigate regional lower limb bone density and associations with weight, PTH, and bone breakdown in coeliac men.<jats:italic>Methods<\/jats:italic>. From whole body DXA scans bone mineral density (BMD) was measured in 28 coeliac men, in the lower limb (subdivided into 6 regions, 3 being metaphyseal (mainly trabecular) and 2 diaphyseal (mainly cortical)). BMD at femoral neck (FN) and lumbar spine L2\u20134, body weight, height, serum calcium, alkaline phosphatase, parathyroid hormone (PTH), and urinary calcium and NTx\/Cr, a measure of bone breakdown, were also measured. Age matched healthy men provided values for BMD calculation of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>z<\/mml:mi><\/mml:mrow><\/mml:math>and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>T<\/mml:mi><\/mml:mrow><\/mml:math>scores and for biochemical measurements.<jats:italic>Results<\/jats:italic>. Low BMD<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>z<\/mml:mi><\/mml:mrow><\/mml:math>scores were found at metaphyseal regions in the leg (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>) and in the FN (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>). The distal metaphyseal region BMD in the leg was lower than spine or FN (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>). PTH, urinary calcium\/creatinine, and urinary NTx\/Cr were similar to controls. Both metaphyseal and diaphyseal BMD<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:mi>z<\/mml:mi><\/mml:mrow><\/mml:math>scores were associated with body weight (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.02<\/mml:mn><\/mml:math>), but not with either PTH or urinary NTx\/Cr.<jats:italic>Conclusions<\/jats:italic>. Low BMD lower limb regions comprising mostly trabecular bone occur early in CD and in the absence of elevated PTH or increased bone resorption. Low BMD is associated with low body weight.<\/jats:p>","DOI":"10.1155\/2016\/4131794","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T21:21:39Z","timestamp":1473369699000},"page":"1-9","source":"Crossref","is-referenced-by-count":1,"title":["Lower Limb Metaphyseal Bone Is Lost in Men with Coeliac Disease and Does Not Relate to Parathyroid Status"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1235-0396","authenticated-orcid":true,"given":"Michael W. 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