{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T18:45:43Z","timestamp":1763837143351,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,10]],"date-time":"2016-10-10T00:00:00Z","timestamp":1476057600000},"content-version":"vor","delay-in-days":283,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Neurodegenerative diseases are one of the most occurring diseases in developed and developing countries. The aim of this work focused on the screening of the natural inhibitors of AChE and BuChE and antioxidants in <jats:italic>Eleutherococcus<\/jats:italic> species. We found that the ethanol extracts of <jats:italic>E. setchuenensis<\/jats:italic> and <jats:italic>E. sessiliflorus<\/jats:italic> showed the strongest inhibition towards AChE (IC<jats:sub>50<\/jats:sub>: 0.3 and 0.3\u2009mg\/mL, resp.). Among chloroform extracts, the most active appeared to be <jats:italic>E. gracilistylus<\/jats:italic> (IC<jats:sub>50<\/jats:sub>: 0.37\u2009mg\/mL). In turn, the ethanol extract of <jats:italic>E. henryi<\/jats:italic> inhibited the strongest BuChE with IC<jats:sub>50<\/jats:sub> value of 0.13\u2009mg\/mL. Among chloroform extracts, <jats:italic>E. gracilistylus<\/jats:italic>, <jats:italic>E. setchuenensis<\/jats:italic>, and <jats:italic>E. sessiliflorus<\/jats:italic> appeared to be the strongest with IC<jats:sub>50<\/jats:sub> values of 0.12, 0.18, and 0.19\u2009mg\/mL. HPTLC screening confirmed the presence of inhibitors in extracts. All extracts exhibited anti\u2010DPPH<jats:sup>\u204e<\/jats:sup> activity and single antioxidants have been identified. To the best of our knowledge, no information was available on this activity of compounds in <jats:italic>Eleutherococcus<\/jats:italic>. These studies provide a biochemical basis for the regulation of AChE and BuChE and encourage us to continue isolation of active compounds.<\/jats:p>","DOI":"10.1155\/2016\/4135135","type":"journal-article","created":{"date-parts":[[2016,10,10]],"date-time":"2016-10-10T21:01:56Z","timestamp":1476133316000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["<i>In Vitro<\/i> Anti\u2010AChE, Anti\u2010BuChE, and Antioxidant Activity of 12 Extracts of <i>Eleutherococcus<\/i> Species"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7821-7002","authenticated-orcid":false,"given":"Daniel","family":"Za\u0142uski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8250-707X","authenticated-orcid":false,"given":"Rafa\u0142","family":"Ku\u017aniewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,10]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/pca.623"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2007.10.004"},{"volume-title":"G\u0142\u00f3wny Urz\u0105d Statystyczny (GUS)","author":"Statystyczny R.","key":"e_1_2_7_3_2"},{"volume-title":"Choroby Wewn\u0119trzne: Stan Wiedzy Na Rok 2010","author":"Szczelik A.","key":"e_1_2_7_4_2"},{"key":"e_1_2_7_5_2","first-page":"30","article-title":"New therapeutic approaches to Alzheimer\u2032s disease","volume":"57","author":"Schneider L. S.","year":"1996","journal-title":"Psychiatry"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1039\/b508966m"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63473-3.00007-1"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2014.1002091"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2016.01.018"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2015.1027891"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X1200701118"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1556\/achrom.22.2010.4.7"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.08046fp"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.05.024"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1434"},{"key":"e_1_2_7_16_2","first-page":"145","article-title":"Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer\u2032s disease, Parkinson\u2032s disease, and related disorders","volume":"3","author":"Ramanan V. K.","year":"2013","journal-title":"American Journal of Neurodegenerative Disorders"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(61)90145-9"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2007.02.002"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.06.014"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.2478\/v10007-010-0006-y"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/12092130"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2003.08.008"},{"key":"e_1_2_7_23_2","first-page":"63","article-title":"In vitro screening for acetylcholonesterase inhibition of Baliospermum montanum, Humboldtia brunonis Wall. var. raktapushpa and Pittosporum viridulum","volume":"3","author":"Biju J.","year":"2013","journal-title":"Journal of Applied Pharmaceutical Science"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1538703"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21091161"},{"key":"e_1_2_7_26_2","first-page":"419","article-title":"In vitro acetylcholinesterase and butyrylcholinesterase inhibitory potentials of Jatropha gossypifolia plant extracts","volume":"73","author":"Saleem H.","year":"2016","journal-title":"Acta Poloniae Pharmaceutica\u2014Drug Research"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/chrsci\/49.3.182"},{"key":"e_1_2_7_28_2","first-page":"240","article-title":"Influence of Polish climate conditions on content and the chemical variation of volatiles in the roots of six Eleutherococcus species and their potential use","volume":"10","author":"Za\u0142uski D.","year":"2016","journal-title":"Records of Natural Products"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2016\/4135135.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2016\/4135135.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2016\/4135135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T01:45:11Z","timestamp":1722908711000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2016\/4135135"}},"subtitle":[],"editor":[{"given":"Marta C.","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1155\/2016\/4135135"],"URL":"https:\/\/doi.org\/10.1155\/2016\/4135135","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"type":"print","value":"1942-0900"},{"type":"electronic","value":"1942-0994"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2016-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4135135"}}