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Acute lung injury\/acute respiratory distress syndrome (ALI\/ARDS) is one of the main clinical complications in severe malaria. The murine model DBA\/2 reproduces the clinical signs of ALI\/ARDS in humans, when infected with<jats:italic>Plasmodium berghei<\/jats:italic>ANKA. High levels of HO-1 were reported in cases of severe malaria. Our data indicated that the HO-1 mRNA and protein expression are increased in mice that develop malaria-associated ALI\/ARDS (MA-ALI\/ARDS). Additionally, the hemin, a HO-1 inducing drug, prevented mice from developing MA-ALI\/ARDS when administered prior to the development of MA-ALI\/ARDS in this model. Also, hemin treatment showed an amelioration of respiratory parameters in mice, high VEGF levels in the sera, and a decrease in vascular permeability in the lung, which are signs of ALI\/ARDS. Therefore, the induction of HO-1 before the development of MA-ALI\/ARDS could be protective. However, the increased expression of HO-1 on the onset of MA-ALI\/ARDS development may represent an effort to revert the phenotype of this syndrome by the host. We therefore confirm that HO-1 inducing drugs could be used for prevention of MA-ALI\/ARDS in humans.<\/jats:p>","DOI":"10.1155\/2016\/4158698","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T23:30:45Z","timestamp":1479252645000},"page":"1-12","source":"Crossref","is-referenced-by-count":30,"title":["Association of Heme Oxygenase 1 with Lung Protection in Malaria-Associated ALI\/ARDS"],"prefix":"10.1155","volume":"2016","author":[{"given":"Marcelo L. 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