{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:27:57Z","timestamp":1787783277421,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010755","name":"Chinese Society of Endocrinology","doi-asserted-by":"crossref","award":["13020120397"],"award-info":[{"award-number":["13020120397"]}],"id":[{"id":"10.13039\/100010755","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010755","name":"Chinese Society of Endocrinology","doi-asserted-by":"crossref","award":["13040630448"],"award-info":[{"award-number":["13040630448"]}],"id":[{"id":"10.13039\/100010755","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010755","name":"Chinese Society of Endocrinology","doi-asserted-by":"crossref","award":["13020120397"],"award-info":[{"award-number":["13020120397"]}],"id":[{"id":"10.13039\/100010755","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010755","name":"Chinese Society of Endocrinology","doi-asserted-by":"crossref","award":["13040630448"],"award-info":[{"award-number":["13040630448"]}],"id":[{"id":"10.13039\/100010755","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To investigate the effect and mechanism of the exenatide on diabetic cardiomyopathy.<jats:italic>Methods<\/jats:italic>. Rats were divided into control group, diabetes group (D), diabetes treated with insulin (DI) group, and diabetes treat with exenatide (DE) group. We detected apoptosis rate by TUNEL, the adiponectin and high molecular weight adiponectin (HMW-adiponectin) by ELISA, and the expression of APPL1, p-AMPK\/T-AMPK, PPAR<jats:italic>\u03b1<\/jats:italic>, and NF-<jats:italic>\u03ba<\/jats:italic>B by immunohistochemistry and western blotting.<jats:italic>Results<\/jats:italic>. Compared with the D group, the apoptosis in the Control and DE groups was decreased (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>); the adiponectin and HMW-adiponectin were increased (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>); the APPL1, p-AMPK\/T-AMPK, PPAR<jats:italic>\u03b1<\/jats:italic>, and LV \u2212<jats:italic>dP\/dt<\/jats:italic>were increased (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>); and the NF-<jats:italic>\u03ba<\/jats:italic>B, GRP78, and LVEDP were decreased (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). Compared with DE group, the glucose levels in the DI group were similar (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>); the apoptosis and LVEDP were increased; the APPL1, p-AMPK\/T-AMPK, PPAR<jats:italic>\u03b1<\/jats:italic>, and LV \u2212<jats:italic>dP\/dt<\/jats:italic>were decreased (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>); the NF-<jats:italic>\u03ba<\/jats:italic>B and GRP78 were increased (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>); the adiponectin and HMW-adiponectin were significantly decreased (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>).<jats:italic>Conclusion<\/jats:italic>. Our model of diabetic cardiomyopathy was constructed successfully. After being treated with exenatide, the adiponectin and HMW-adiponectin and the APPL1-AMPK-PPAR<jats:italic>\u03b1<\/jats:italic>axis were increased, the NF-<jats:italic>\u03ba<\/jats:italic>B and the apoptosis were decreased, the cardiac function of the diabetic rats was improved, and these effects were independent of glucose control.<\/jats:p>","DOI":"10.1155\/2016\/4219735","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T21:42:52Z","timestamp":1448919772000},"page":"1-10","source":"Crossref","is-referenced-by-count":21,"title":["Exenatide Activates the APPL1-AMPK-PPAR<i>\u03b1<\/i>Axis to Prevent Diabetic Cardiomyocyte Apoptosis"],"prefix":"10.1155","volume":"2016","author":[{"given":"Lei","family":"XiaoTian","sequence":"first","affiliation":[{"name":"Endocrine Department, The First Affiliated Hospital of the Third Military Medical University, Chongqing 400038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"QiNan","sequence":"additional","affiliation":[{"name":"Endocrine Department, The First Affiliated Hospital of the Third Military Medical University, Chongqing 400038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gan","family":"XiaGuang","sequence":"additional","affiliation":[{"name":"Endocrine Department, The First Affiliated Hospital of the Third Military Medical University, Chongqing 400038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng","family":"WuQuan","sequence":"additional","affiliation":[{"name":"Endocrine Department, The First Affiliated Hospital of the Third Military Medical University, Chongqing 400038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Bing","sequence":"additional","affiliation":[{"name":"Endocrine Department, The First Affiliated Hospital of the Third Military Medical University, 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