{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T19:51:35Z","timestamp":1780948295035,"version":"3.54.1"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. Similar to PET, absolute quantitative imaging is becoming available in commercial SPECT\/CT devices. This study\u2019s goal was to assess quantitative accuracy of activity recovery as a function of image reconstruction parameters and count statistics in a variety of phantoms.<jats:italic> Materials and Methods<\/jats:italic>. We performed quantitative <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mmultiscripts><mml:mrow><mml:mi mathvariant=\"normal\">T<\/mml:mi><mml:mi mathvariant=\"normal\">c<\/mml:mi><\/mml:mrow><mml:mprescripts\/><mml:none\/><mml:mrow><mml:mn mathvariant=\"normal\">99<\/mml:mn><mml:mi mathvariant=\"normal\">m<\/mml:mi><\/mml:mrow><\/mml:mmultiscripts><\/mml:mrow><\/mml:math>-SPECT\/CT acquisitions (Siemens Symbia Intevo, Erlangen, Germany) of a uniform cylindrical, NEMA\/IEC, and an anthropomorphic abdominal phantom. Background activity concentrations tested ranged: 2\u201380\u2009kBq\/mL. SPECT acquisitions used 120 projections (20\u2009s\/projection). Reconstructions were performed with the proprietary iterative conjugate gradient algorithm. NEMA phantom reconstructions were obtained as a function of the iteration number (range: 4\u201348). Recovery coefficients, hot contrast, relative lung error (NEMA phantom), and image noise were assessed.<jats:italic> Results<\/jats:italic>. In all cases, absolute activity and activity concentration were measured within 10% of the expected value. Recovery coefficients and hot contrast in hot inserts did not vary appreciably with count statistics. RC converged at 16 iterations for insert size &gt; 22\u2009mm. Relative lung errors were comparable to PET levels indicating the efficient integration of attenuation and scatter corrections with adequate detector modeling.<jats:italic> Conclusions<\/jats:italic>. The tested device provided accurate activity recovery within 10% of correct values; these performances are comparable to current generation PET\/CT systems.<\/jats:p>","DOI":"10.1155\/2016\/4360371","type":"journal-article","created":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T18:46:23Z","timestamp":1481741183000},"page":"1-6","source":"Crossref","is-referenced-by-count":45,"title":["Phantom Validation of Tc-99m Absolute Quantification in a SPECT\/CT Commercial Device"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6547-3824","authenticated-orcid":true,"given":"Silvano","family":"Gnesin","sequence":"first","affiliation":[{"name":"Institute of Radiation Physics, Lausanne University Hospital, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Leite Ferreira","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Malterre","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscille","family":"Laub","sequence":"additional","affiliation":[{"name":"Institute of Radiation Physics, Lausanne University Hospital, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John O.","family":"Prior","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis R.","family":"Verdun","sequence":"additional","affiliation":[{"name":"Institute of Radiation Physics, Lausanne University Hospital, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/mnm.0b013e3282f3a515"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-013-2542-4"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.111476"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2011.1063"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.2967\/jnmt.107.046839"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/56\/14\/R01"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.071571"},{"issue":"9","key":"8","first-page":"1519","volume":"45","year":"2004","journal-title":"Journal of Nuclear Medicine"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-009-1297-4"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1118\/1.3635220"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2016\/4360371.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2016\/4360371.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2016\/4360371.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T18:46:23Z","timestamp":1481741183000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2016\/4360371\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":10,"alternative-id":["4360371","4360371"],"URL":"https:\/\/doi.org\/10.1155\/2016\/4360371","relation":{},"ISSN":["1748-670X","1748-6718"],"issn-type":[{"value":"1748-670X","type":"print"},{"value":"1748-6718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}