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Oxidative stress is associated with infertility. This study was conducted to determine the effects of glutamate and aspartate on serum antioxidative enzymes, sex hormones, and genital inflammation in boars suffering from oxidative stress.<jats:italic>Methods<\/jats:italic>. Boars were randomly divided into 4 groups: the nonchallenged control (CON) and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>-challenged control (BD) groups were fed a basal diet supplemented with 2% alanine; the other two groups were fed the basal diet supplemented with 2% glutamate (GLU) or 2% aspartate (ASP). The BD, GLU, and ASP groups were injected with hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) on day 15. The CON group was injected with 0.9% sodium chloride solution on the same day.<jats:italic>Results<\/jats:italic>. Dietary aspartate decreased the malondialdehyde (MDA) level in serum (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>) compared with the BD group. Additionally, aspartate maintained serum luteinizing hormone (LH) at a relatively stable level. Moreover, glutamate and aspartate increased transforming growth factor-<jats:italic>\u03b2<\/jats:italic>1 (TGF-<jats:italic>\u03b2<\/jats:italic>1) and interleukin-10 (IL-10) levels in the epididymis and testis (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>) compared with the BD group.<jats:italic>Conclusion<\/jats:italic>. Both glutamate and aspartate promoted genital mRNA expressions of anti-inflammatory factors after oxidative stress. Aspartate more effectively decreased serum MDA and prevented fluctuations in serum sex hormones after H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>challenge than did glutamate.<\/jats:p>","DOI":"10.1155\/2016\/4394695","type":"journal-article","created":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T22:10:17Z","timestamp":1475187017000},"page":"1-10","source":"Crossref","is-referenced-by-count":18,"title":["Effects of Glutamate and Aspartate on Serum Antioxidative Enzyme, Sex Hormones, and Genital Inflammation in Boars Challenged with Hydrogen Peroxide"],"prefix":"10.1155","volume":"2016","author":[{"given":"Hengjia","family":"Ni","sequence":"first","affiliation":[{"name":"Key Laboratory for Agro-Ecological Processes in Subtropical Region, Hunan Research Center of Livestock and Poultry Sciences, South Central Experimental Station of Animal Nutrition and Feed Science in the Ministry of Agriculture, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Hunan, 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