{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:48:14Z","timestamp":1787500094068,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T00:00:00Z","timestamp":1463356800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondo Nacional de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","award":["G-98003462"],"award-info":[{"award-number":["G-98003462"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology Research International"],"published-print":{"date-parts":[[2016,5,16]]},"abstract":"<jats:p>\n                    Trypanosomosis, a globally occurring parasitic disease, poses as a major obstacle to livestock production in tropical and subtropical regions resulting in tangible economic losses. In Latin America including Venezuela, trypanosomosis of ruminants is mainly caused by\n                    <jats:italic>Trypanosoma vivax<\/jats:italic>\n                    . Biologically active substances produced from trypanosomes, as well as host-trypanosome cellular interactions, contribute to the pathogenesis of anemia in an infection. The aim of this study was to examine with a scanning electron microscope the cellular interactions and alterations in ovine red blood cells (RBC) experimentally infected with\n                    <jats:italic>T. vivax<\/jats:italic>\n                    . Ovine infection resulted in changes of RBC shape as well as the formation of surface holes or vesicles. A frequent observation was the adhesion to the ovine RBC by the trypanosome\u2019s free flagellum, cell body, or attached flagellum in a process mediated by the filopodia emission from the trypanosome surface. The observed RBC alterations are caused by mechanical and biochemical damage from host-parasite interactions occurring in the bloodstream. The altered erythrocytes are prone to mononuclear phagocytic removal contributing to the hematocrit decrease during infection.\n                  <\/jats:p>","DOI":"10.1155\/2016\/4503214","type":"journal-article","created":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T17:01:20Z","timestamp":1463418080000},"page":"1-9","source":"Crossref","is-referenced-by-count":8,"title":["<i>Trypanosoma vivax<\/i>\n                    Adhesion to Red Blood Cells in Experimentally Infected Sheep"],"prefix":"10.1155","volume":"2016","author":[{"given":"Alpidio A.","family":"Boada-Sucre","sequence":"first","affiliation":[{"name":"Laboratorio de Microscop\u00eda Electr\u00f3nica, Centro de Estudios Biom\u00e9dicos y Veterinarios, Instituto de Estudios Cient\u00edficos y Tecnol\u00f3gicos, Universidad Nacional Experimental Sim\u00f3n Rodr\u00edguez, Caracas, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello Salvatore","family":"Rossi Spadafora","sequence":"additional","affiliation":[{"name":"Unidad de Toxoplasmosis y Protozoosis, Departamento de Parasitolog\u00eda, Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, Calle Alejandro Casona 7, Piso 6D, 28035 Madrid, Spain"},{"name":"Secci\u00f3n de Inmunohistoqu\u00edmica y Microscop\u00eda Electr\u00f3nica, Instituto Anatomopatol\u00f3gico \u201cJos\u00e9 A. 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